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. 2016 Oct;3(5):119-127.
doi: 10.1177/2049936116666983. Epub 2016 Oct 12.

Bloodstream infections and antimicrobial sensitivity patterns in a tertiary care hospital of India

Nikita Vasudeva  1 , Prem Singh Nirwan  2 , Preeti Shrivastava  2
Affiliations

Bloodstream infections and antimicrobial sensitivity patterns in a tertiary care hospital of India

Nikita Vasudeva et al. Ther Adv Infect Dis. 2016 Oct.

Abstract

Background: Invasion of the bloodstream by microorganisms constitutes one of the most serious situations in infectious disease. Microorganisms present in circulating blood whether continuously, intermittently, or transiently are a threat to every organ in the body. Prevalence and antimicrobial susceptibility of microorganisms vary depending upon the geography and the use of antibiotics.

Methods: A cross-sectional study to determine the prevalent organisms causing bloodstream infection was conducted. BACTEC BD 9050 system was used to identify the causative organism, and sub-cultures were done on MacConkey Agar and Blood Agar. Antibiotic susceptibility test (AST) was done using Kirby B Disk diffusion method.

Results: A total of 170 patients were enrolled, and blood samples of 53 patients showed growth of organisms. Staphylococcus aureus was the most commonly isolated organism. Most of the Gram-positive cocci (GPC) were susceptible to vancomycin and linezolid. Most of the Gram-negative bacilli (GNB) showed sensitivity to cefoperazone/sulbactam followed by imipenem.

Keywords: Antibiotic Sensitivity; Antimicrobial resistance BACTEC; Blood Stream infections.

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Conflict of interest statement

The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
BACTEC BD 9050 system used for automated cultures.
Figure 2.
Figure 2.
(a) IMVIC tests for Escherichia. coli and (b) fermentation tests for GNB. GNB, Gram-negative bacilli.
Figure 3.
Figure 3.
Age-wise distribution of culture-positive patients.
Figure 4.
Figure 4.
Distribution of GPC isolated from the cultures. GPC, Gram-positive cocci.
Figure 5.
Figure 5.
Distribution of GNB isolated from the cultures. GNB, Gram-negative bacilli.
Figure 6.
Figure 6.
(a) Antibiotic susceptibility pattern of gram negative bacilli and (b) antibiotic susceptibility pattern of Pseudomonas.
See this image and copyright information in PMC

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