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Review
. 2017 Mar;8(2):131-137.
doi: 10.1016/j.jare.2016.11.005. Epub 2016 Dec 12.

Hepatitis C virus and non-Hodgkin's lymphomas: A minireview

Hussein Khaled  1 , Fouad Abu-Taleb  2 , Rasha Haggag  2
Affiliations
Review

Hepatitis C virus and non-Hodgkin's lymphomas: A minireview

Hussein Khaled et al. J Adv Res. 2017 Mar.

Abstract

B-cell NHL is strongly associated with HCV that was proved in the last 2 decades. The most common HCV infection related B-NHL subtypes include MZL and DLBCL lymphomas. HCV-positive NHL patients usually present with older age at diagnosis, higher LDH, and more extranodal disease. The standard chemo-immunotherapy tolerance is generally good. Antiviral treatment achieves virological and hematological remission in HCV associated indolent lymphoma. More aggressive lymphoma requires combination of antiviral treatment and chemotherapy. New generation of HCV antiviral drugs is safe and is highly efficacious. Regimens including DAAs appear promising options as they can reduce the HCV-associated NHL incidence by dramatically lowering the HCV chronic carriers.

Keywords: Antiviral treatment; Hepatitis C virus; Non-Hodgkin lymphoma; Pathogenesis.

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Figures

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Graphical abstract
Fig. 1
Fig. 1
Pathogenesis of HCV-related lymphomagenesis. Adopted from Zignego et al. .
Fig. 2
Fig. 2
An approach to the management of HCV positive cancer patients who are undergoing chemotherapy. Adopted from .
None
See this image and copyright information in PMC

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