Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2017 Mar;8(2):131-137.
doi: 10.1016/j.jare.2016.11.005. Epub 2016 Dec 12.

Hepatitis C virus and non-Hodgkin's lymphomas: A minireview

Hussein Khaled  1 , Fouad Abu-Taleb  2 , Rasha Haggag  2
Affiliations
Review

Hepatitis C virus and non-Hodgkin's lymphomas: A minireview

Hussein Khaled et al. J Adv Res. 2017 Mar.

Abstract

B-cell NHL is strongly associated with HCV that was proved in the last 2 decades. The most common HCV infection related B-NHL subtypes include MZL and DLBCL lymphomas. HCV-positive NHL patients usually present with older age at diagnosis, higher LDH, and more extranodal disease. The standard chemo-immunotherapy tolerance is generally good. Antiviral treatment achieves virological and hematological remission in HCV associated indolent lymphoma. More aggressive lymphoma requires combination of antiviral treatment and chemotherapy. New generation of HCV antiviral drugs is safe and is highly efficacious. Regimens including DAAs appear promising options as they can reduce the HCV-associated NHL incidence by dramatically lowering the HCV chronic carriers.

Keywords: Antiviral treatment; Hepatitis C virus; Non-Hodgkin lymphoma; Pathogenesis.

PubMed Disclaimer

Figures

None
Graphical abstract
Fig. 1
Fig. 1
Pathogenesis of HCV-related lymphomagenesis. Adopted from Zignego et al. .
Fig. 2
Fig. 2
An approach to the management of HCV positive cancer patients who are undergoing chemotherapy. Adopted from .
None
See this image and copyright information in PMC

References

    1. Ghany M.G., Strader D.B., Thomas D.L., Seeff L.B. Diagnosis, management, and treatment of hepatitis C: an update. Hepatology. 2009;49:1335–1374. - PMC - PubMed
    1. Durand T., Di Liberto G., Colman H., Cammas A., Boni S., Marcellin P. Occult infection of peripheral B cells by hepatitis C variants which have low translational efficiency in cultured hepatocytes. Gut. 2010;59:934–942. - PubMed
    1. Simonetti R.G., Camma C., Fiorello F., Cottone M., Rapicetta M., Marino L. Hepatitis C virus infection as a risk factor for hepatocellular carcinoma in patients with cirrhosis. A case-control study. Ann Intern Med. 1992;116:97–102. - PubMed
    1. Waked I., Doss W., El-Sayed M.H., Estes C., Razavi H., Shiha G. The current and future disease burden of chronic hepatitis C virus infection in Egypt. Arab J Gastroenterol. 2014;15:45–52. - PubMed
    1. Shepard C.W., Finelli L., Alter M.J. Global epidemiology of hepatitis C virus infection. Lancet Infect Dis. 2005;5:558–567. - PubMed

LinkOut - more resources