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. 2016 Dec;4(24):479.
doi: 10.21037/atm.2016.12.52.

Effects of curcumin on Helicobacter pylori infection

Vaclav Vetvicka  1 , Jana Vetvickova  1 , Rafael Fernandez-Botran  1
Affiliations

Effects of curcumin on Helicobacter pylori infection

Vaclav Vetvicka et al. Ann Transl Med. 2016 Dec.

Erratum in

Abstract

Background: Curcumin is a well-established natural molecule with significant biological and pharmaceutical effects. Its effects on Helicobacter pylori (H. pylori) infection have been repeatedly confirmed both in animal and human models. This study directly compared five different samples to evaluate if the effects are general or if they differ among samples.

Methods: Using a mouse model, we studied the effects of curcumin on lipid peroxide (LPO) level, myeloperoxidase (MPO) and urease activity, number of colonized bacteria, levels of anti-H. pylori antibodies, biofilm formation, IFN-γ, IL-4, gastrin and somatostatin levels in serum, and minimum inhibitory concentration. In addition, we evaluated the effects on biofilm production and antibacterial antibody response.

Results: In all tests, one sample (Sabinsa) was consistently the most active.

Conclusions: All curcumin samples showed some anti-H. pylori effects, but only some of the tested samples had significant activity.

Keywords: Biofilm; Helicobacter pylori (H. pylori); curcumin.

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Conflict of interest statement

The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
Effects of curcumin on serum levels of IL-4. Results represent mean from three experiments ± SD. *, represents significant differences between the control and curcumin-treated mice at P≤0.05 level.
Figure 2
Figure 2
Effects of curcumin on serum levels of IFN-γ. Results represent mean from three experiments ± SD. *, represents significant differences between the control and curcumin-treated mice at P≤0.05 level.
Figure 3
Figure 3
Effects of curcumin on serum levels of somatostatin. Results represent mean from three experiments ± SD. *, represents significant differences between the control and curcumin-treated mice at P≤0.05 level.
Figure 4
Figure 4
Effects of curcumin on serum levels of gastrin. Results represent mean from three experiments ± SD. *, represents significant differences between the control and curcumin-treated mice at P≤0.05 level.
Figure 5
Figure 5
Effects of curcumin on LPO abundance in gastric mucosal tissue. Results represent mean from three experiments ± SD. *, represents significant differences between the control and curcumin-treated mice at P≤0.05 level. LPO, lipid peroxide.
Figure 6
Figure 6
Effects of curcumin on MPO activity in gastric mucosal tissue. Results represent mean from three experiments ± SD. *, represents significant differences between the control and curcumin-treated mice at P≤0.05 level. MPO, myeloperoxidase.
Figure 7
Figure 7
Effects of curcumin on anti-H. pylori IgG formation. Results represent mean from three experiments ± SD. *, represents significant differences between the control and curcumin-treated mice at P≤0.05 level. H. pylori, Helicobacter pylori.
See this image and copyright information in PMC

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