Defensin-chemokine heteromeric complexes derived from heterocellular activation-a possible target to inhibit CCL5 in cardiovascular settings

Affiliations

¹ Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.
² Department of Radiology, Washington University School of Medicine, St. Louis, MO, USA.

Editorial

Osamu Baba et al. Ann Transl Med. 2016 Dec.

. 2016 Dec;4(24):497.

doi: 10.21037/atm.2016.11.46.

¹ Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.
² Department of Radiology, Washington University School of Medicine, St. Louis, MO, USA.

No abstract available

Conflict of interest statement

The authors have no conflicts of interest to declare.

Recruitment of classical monocytes can be inhibited by disturbing heteromers of neutrophil HNP1 and platelet CCL5.
Alard JE, Ortega-Gomez A, Wichapong K, Bongiovanni D, Horckmans M, Megens RT, Leoni G, Ferraro B, Rossaint J, Paulin N, Ng J, Ippel H, Suylen D, Hinkel R, Blanchet X, Gaillard F, D'Amico M, von Hundelshausen P, Zarbock A, Scheiermann C, Hackeng TM, Steffens S, Kupatt C, Nicolaes GA, Weber C, Soehnlein O. Alard JE, et al. Sci Transl Med. 2015 Dec 9;7(317):317ra196. doi: 10.1126/scitranslmed.aad5330. Sci Transl Med. 2015. PMID: 26659570

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