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Editorial
. 2016 Dec;4(24):513.
doi: 10.21037/atm.2016.12.30.

Protection against lupus-like inflammatory disease is in the LAP of non-canonical autophagy

Thomas Scambler  1 , Conor Feeley  1 , Michael F McDermott  1
Affiliations
Editorial

Protection against lupus-like inflammatory disease is in the LAP of non-canonical autophagy

Thomas Scambler et al. Ann Transl Med. 2016 Dec.
No abstract available

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Conflict of interest statement

The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
The canonical and non-canonical autophagy pathways. Apoptotic cell debris is phagocytosed and directed to the LAP pathway of autophagy. When the contents of phagosomes escape into the cytoplasm, canonical autophagy is the preferred pathway. Both pathways share certain proteins (green), whereas some are canonical specific (pink) and some are specific to the LAP pathway (purple). LAP, LC3-associated phagocytosis; Tim4, T cell immunoglobulin- and mucin domain-containing molecule-4; ATG, autophagy-related; Nox2, NADPH oxidase; Fip200, FAK family-interacting protein of 200 kDa; Ulk1, uncoordinated (Unc)-51-like kinase 1; LC3, Microtubule-associated protein 1A/1B-light chain 3.
See this image and copyright information in PMC

Comment on

References

    1. McGonagle D, McDermott MF. A Proposed Classification of the Immunological Diseases. PLoS Med 2006;3:e297. 10.1371/journal.pmed.0030297 - DOI - PMC - PubMed
    1. Nagy G, Koncz A, Perl A. T- and B-cell abnormalities in systemic lupus erythematosus. Crit Rev Immunol 2005;25:123-40. 10.1615/CritRevImmunol.v25.i2.30 - DOI - PubMed
    1. Schneider L, Dos Santos AS, Santos M, et al. Vitamin D and systemic lupus erythematosus: state of the art. Clin Rheumatol 2014;33:1033-8. - PubMed
    1. Hochberg MC. Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 1997;40:1725. 10.1002/art.1780400928 - DOI - PubMed
    1. Petri M, Orbai AM, Alarcón GS, et al. Derivation and validation of the Systemic Lupus International Collaborating Clinics classification criteria for systemic lupus erythematosus. Arthritis Rheum 2012;64:2677-86. 10.1002/art.34473 - DOI - PMC - PubMed