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Comment
. 2016 Dec;4(24):533.
doi: 10.21037/atm.2016.11.71.

Finding ways to solve or prevent aminoglycoside-induced ototoxicity?

Jin Li  1 , Connie W Woo  2
Affiliations
Comment

Finding ways to solve or prevent aminoglycoside-induced ototoxicity?

Jin Li et al. Ann Transl Med. 2016 Dec.
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
Endotoxemic conditions aggravate AG-induced ototoxicity. Disease states such as bacterial infection, obesity, autoimmune diseases are associated with the increased circulating LPS level. LPS binds to TLR4 resulting in augmented production of pro-inflammatory molecules. The increased pro-inflammatory proteins promote the dilation of the strial capillaries, which further increases the accumulation of AG and worsens the auditory toxicity.
See this image and copyright information in PMC

Comment on

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