UniProt Protein Knowledgebase

Abstract

The Universal Protein Resource (UniProt) is a freely available comprehensive resource for protein sequence and annotation data. UniProt is a collaboration between the European Bioinformatics Institute (EMBL-EBI), the Swiss Institute of Bioinformatics (SIB), and the Protein Information Resource (PIR). Across the three institutes more than 100 people are involved through different tasks such as expert curation, software development, and support.This chapter introduces the functionality and data provided by UniProt. It describes example use cases for which you might come to UniProt and the methods to help you achieve your goals.

Keywords: Protein data; Protein tools; UniProt.

Fig. 1

Overview of key UniProt datasets

Fig. 2

UniProt header search bar

Fig. 3

Advanced search

Fig. 4

UniProtKB search results page

Fig. 5

UniProtKB protein entry

Fig. 6

Proteomes results page

Fig. 7

Human Proteome entry

Fig. 8

Human diseases results page

Fig. 9

BLAST input page

Fig. 10

BLAST results page

Fig. 11

Align results page

Fig. 12

Retrieve/ID mapping results page from UniProt to external IDs

Fig. 13

Retrieve/ID mapping results page from external database to UniProt ACs

Fig. 14

Retrieve/ID mapping results page for batch UniProtKB entry retrieval