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Randomized Controlled Trial
. 2017 Jan;81(1):22-27.

Analysis of efficacy obtained with a trivalent inactivated Haemophilus parasuis serovars 4, 5, and 12 vaccine and commercial vaccines against Glässer's disease in piglets

Zhanqin Zhao  1 , Huisheng Liu  1 , Yun Xue  1 , Kunpeng Chen  1 , Zhijun Liu  1 , Qiao Xue  1 , Chen Wang  1
Affiliations
Randomized Controlled Trial

Analysis of efficacy obtained with a trivalent inactivated Haemophilus parasuis serovars 4, 5, and 12 vaccine and commercial vaccines against Glässer's disease in piglets

Zhanqin Zhao et al. Can J Vet Res. 2017 Jan.

Abstract
in English, French

The objective of this study was to assess the efficacy of a trivalent inactivated Haemophilus parasuis serovars 4, 5, and 12 vaccine with polymeric adjuvant gel (GEL) and commercial vaccines against Glässer's disease in piglets. Commercial vaccines containing inactivated H. parasuis serovars 4 and 5 (China), inactivated H. parasuis serovars 1 and 6 (Spain), and inactivated H. parasuis serovar 5 (USA) were also evaluated. Our results demonstrated that the trivalent inactivated H. parasuis serovars 4, 5, and 12 vaccine with GEL adjuvant can provide better protection against the 3 most common pathogenic serovars circulating in China than other commercial vaccines tested. Our findings also indicated that inactivated H. parasuis serovars 1 and 6 vaccine cross-protects piglets against H. parasuis serovars 4 and 5; inactivated H. parasuis serovar 5 vaccine cross-protects piglets against H. parasuis serovar 4 challenge; but none of the commercial vaccines tested in this study protected piglets against H. parasuis serovar 12. Our results provide a basis for further identification of common protective antigens that can induce cross-protection against heterogeneous serovars.

L’objectif de la présente étude était d’évaluer l’efficacité d’un vaccin inactivé trivalent contre Haemophilus parasuis contenant les sérovars 4, 5 et 12 avec un adjuvant en gel polymérique (GEL) et des vaccins commerciaux contre la maladie de Glässer chez des porcelets. Des vaccins commerciaux contenant du H. parasuis inactivé sérovars 4 et 5 (Chine), du H. parasuis inactivé sérovars 1 et 6 (Espagne), et du H. parasuis inactivé sérovar 5 (États-Unis) ont également été évalués. Nos résultats démontrent que le vaccin inactivé trivalent contenant H. parasuis sérovars 4, 5 et 12 avec l’adjuvant GEL peut fournir une meilleure protection contre les trois sérovars les plus fréquents circulant en Chine que les autres vaccins commerciaux testés. Nos trouvailles indiquent également que le vaccin contenant H. parasuis inactivé sérovars 1 et 6 offre une protection croisée contre H. parasuis sérovars 4 et 5; le vaccin inactivé H. parasuis sérovar 5 offre une protection croisée contre un challenge avec H. parasuis sérovar 4; mais qu’aucun des vaccins commerciaux testés dans l’étude ne protège les porcelets contre H. parasuis sérovar 12. Nos résultats fournissent une base pour l’identification future d’antigènes protecteurs communs qui peuvent induire une protection contre des sérovars hétérologues.(Traduit par Docteur Serge Messier).

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References

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