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. 2017 Feb 21;46(8):2524-2531.
doi: 10.1039/c6dt04833a.

Intracellular detection of hazardous Cd2+ through a fluorescence imaging technique by using a nontoxic coumarin based sensor

Chanda Kumari  1 , Dibyendu Sain  2 , Ashish Kumar  1 , Sushanta Debnath  3 , Partha Saha  3 , Swapan Dey  1
Affiliations

Intracellular detection of hazardous Cd2+ through a fluorescence imaging technique by using a nontoxic coumarin based sensor

Chanda Kumari et al. Dalton Trans. .

Abstract

A new coumarin based turn on fluorescent sensor (R1) was reported for the detection of highly hazardous Cd2+ with excellent selectivity and sensitivity without any interference of other metal ions. The single crystal X-ray structure analysis of the sensor showed the actual geometry of the molecule. For the first time, a Cd2+ induced FRET mechanism was observed and explained accordingly. Instant naked eye detection of Cd2+ through a sharp colour change signified the practical applicability of R1. The sensor of high quantum yield was applied in the intracellular detection of poisonous Cd2+ in living HeLa S3 cells.

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