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Review
. 2017 Jun;124(6):709-713.
doi: 10.1007/s00702-017-1692-0. Epub 2017 Feb 2.

Parkinson's disease as a multisystem disorder

Lisa Klingelhoefer  1 , H Reichmann  2
Affiliations
Review

Parkinson's disease as a multisystem disorder

Lisa Klingelhoefer et al. J Neural Transm (Vienna). 2017 Jun.

Abstract

This article summarises the noteworthy contribution of Professor Jellinger to the understanding of Parkinson's disease (PD) as a disease affecting multiple body- and neurotransmitter-systems. Phosphorylated alpha-synuclein and the formation of Lewy pathology as neuropathological hallmarks of PD seem to spread from the enteric nervous system and the olfactory bulb in a rostrocranial direction to the CNS. Subsequently, a progressive degeneration of the dopaminergic-nigrostriatal system and widespread extranigral pathology affecting different anatomical structures and neurotransmitters are induced causing the various non-motor and motor symptoms of PD.

Keywords: Alpha-synuclein; NMS; Non-motor symptoms; PD; Parkinson’s disease; Proteinopathy.

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