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Editorial
. 2017 Apr;83(4):685-687.
doi: 10.1111/bcp.13230. Epub 2017 Feb 2.

Why standards are useful for predicting doses

Nick H G Holford  1 , Brian J Anderson  2
Affiliations
Editorial

Why standards are useful for predicting doses

Nick H G Holford et al. Br J Clin Pharmacol. 2017 Apr.

Abstract

Germovsek and colleagues have recently concluded that a standard approach to modelling pharmacokinetics is not wrong and appears to be at least as useful as other ad hoc methods for describing drug concentrations. There are other advantages of this approach including learning about biology, comparing different studies, detecting errors and rationalizing dose prediction. A standard approach to size and maturation is not a panacea but provides the framework for challenging new ideas and supports a consistent method of dosing in patients of all ages.

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Figures

Figure 1
Figure 1
Different biological mechanisms of elimination are shown as a function of postnatal age (PNA) using theory based allometric size scaling. Glomerular filtration rate (GFR) may be seen as a reference for the different rates of maturation of common metabolic pathways. Sources: GFR 14, vancomycin data pooled from 15, 16, paracetamol 8, morphine 8, tramadol 17, busulfan 12
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References

    1. Southan C, Sharman JL, Benson HE, Faccenda E, Pawson AJ, Alexander SP, et al. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. Nucleic Acids Res 2016; 44 (D1): D1054–68. - PMC - PubMed
    1. Germovsek E, Barker C, Sharland M, Standing JF. Scaling clearance in paediatric pharmacokinetics: all models are wrong, which are useful? Br J Clin Pharmacol 2017; 83: 777–790. - PMC - PubMed
    1. West GB, Brown JH, Enquist BJ. The fourth dimension of life: fractal geometry and allometric scaling of organisms. Science 1999; 284: 1677–1679. - PubMed
    1. Niklas KJ, Kutschera U. Kleiber's law: how the fire of life ignited debate, fueled theory, and neglected plants as model organisms. Plant Signal Behav 2015; 10: e1036216. - PMC - PubMed
    1. Holford N, Heo YA, Anderson B. A pharmacokinetic standard for babies and adults. J Pharm Sci 2013; 102: 2941–2952. - PubMed

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