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Editorial
. 2017 Jan 14;38(3):198-200.
doi: 10.1093/eurheartj/ehw085.

Neutrophil-macrophage cross-talk in acute myocardial infarction

Vanessa Frodermann  1 , Matthias Nahrendorf  1
Affiliations
Editorial

Neutrophil-macrophage cross-talk in acute myocardial infarction

Vanessa Frodermann et al. Eur Heart J. .
No abstract available

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Figures

Figure 1
Figure 1
Neutrophil–macrophage cross-talk in acute myocardial infarction. Neutrophil depletion reduces Ly-6Chi monocyte recruitment from the splenic reservoir. Lack of neutrophil neutrophil-derived lipocalin (NGAL) reduces myeloid–epithelial–reproductive tyrosine kinase (MerTK) expression in cardiac macrophages, thereby impairing their clearance of cellular debris. Cardiac macrophages proliferate in the absence of neutrophils and adopt a reparative phenotype, inducing prominent fibrosis.
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