Epithelial organoid cultures from patients with ulcerative colitis and Crohn's disease: a truly long-term model to study the molecular basis for inflammatory bowel disease?

Manuel Noben^{1

2}, Bram Verstockt¹, Magali de Bruyn^{1

3}, Nikolai Hendriks^{1

2}, Gert Van Assche^{1

4}, Séverine Vermeire^{1

4}, Catherine Verfaillie², Marc Ferrante^{1

4}

Affiliations

¹ Department of Clinical and Experimental Medicine, Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven, Leuven, Belgium.
² Department of Development and Regeneration, Stem Cell Institute Leuven, KU Leuven, Leuven, Belgium.
³ Department of Microbiology and Immunology, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.
⁴ Department of Gastroenterology and Hepatology, University Hospitals Leuven, KU Leuven, Belgium.

PMID: 28159838
DOI: 10.1136/gutjnl-2016-313667

Comment

Epithelial organoid cultures from patients with ulcerative colitis and Crohn's disease: a truly long-term model to study the molecular basis for inflammatory bowel disease?

Manuel Noben et al. Gut. 2017 Dec.

. 2017 Dec;66(12):2193-2195.

doi: 10.1136/gutjnl-2016-313667. Epub 2017 Feb 3.

Authors

Manuel Noben^{1

2}, Bram Verstockt¹, Magali de Bruyn^{1

3}, Nikolai Hendriks^{1

2}, Gert Van Assche^{1

4}, Séverine Vermeire^{1

4}, Catherine Verfaillie², Marc Ferrante^{1

4}

Affiliations

¹ Department of Clinical and Experimental Medicine, Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven, Leuven, Belgium.
² Department of Development and Regeneration, Stem Cell Institute Leuven, KU Leuven, Leuven, Belgium.
³ Department of Microbiology and Immunology, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.
⁴ Department of Gastroenterology and Hepatology, University Hospitals Leuven, KU Leuven, Belgium.

PMID: 28159838
DOI: 10.1136/gutjnl-2016-313667

No abstract available

Keywords: GENE EXPRESSION; IBD MODELS; INFLAMMATORY BOWEL DISEASE; INTESTINAL EPITHELIUM; ULCERATIVE COLITIS.

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Conflict of interest statement

Competing interests: SV: Grant support: AbbVie, MSD and Takeda; Speaker fees: AbbVie, MSD, Takeda, Ferring, Dr Falk Pharma, Hospira, Pfizer and Tillots; Consultancy: AbbVie, MSD, Takeda, Ferring, Genentech/Roche, Shire, Pfizer, Galapagos, Mundipharma, Hospira, Celgene, Second Genome and Janssen. GVA: Financial support for research: Abbvie, MSD; Lecture fees: Abbvie, Ferring, MSD, Janssen, Takeda; Consultancy: Abbvie, MSD, Takeda. MF: Research grant: Takeda; Speakers fee: Abbvie, Boehringer-Ingelheim, Chiesi, Falk, Ferring, Janssen, Mitsubishi Tanabe, MSD, Takeda, Tillotts, Zeria; Consultancy: Abbvie, Boehringer-Ingelheim, Ferring, Janssen, MSD.

Comment on

Alterations in the epithelial stem cell compartment could contribute to permanent changes in the mucosa of patients with ulcerative colitis.
Dotti I, Mora-Buch R, Ferrer-Picón E, Planell N, Jung P, Masamunt MC, Leal RF, Martín de Carpi J, Llach J, Ordás I, Batlle E, Panés J, Salas A. Dotti I, et al. Gut. 2017 Dec;66(12):2069-2079. doi: 10.1136/gutjnl-2016-312609. Epub 2016 Nov 1. Gut. 2017. PMID: 27803115 Free PMC article.

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Epithelial organoid cultures from patients with ulcerative colitis and Crohn's disease: a truly long-term model to study the molecular basis for inflammatory bowel disease?

Affiliations

Epithelial organoid cultures from patients with ulcerative colitis and Crohn's disease: a truly long-term model to study the molecular basis for inflammatory bowel disease?

Authors

Affiliations

Conflict of interest statement

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Medical