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. 2017 Mar;24(9):8279-8286.
doi: 10.1007/s11356-017-8487-6. Epub 2017 Feb 3.

Influence of nonylphenol and octylphenol exposure on 5-HT, 5-HT transporter, and 5-HT2A receptor

Chunhong Liu  1   2   3 , Yuting Lai  4 , Junyan Ouyang  4 , Tongwang Yang  4 , Youting Guo  4 , Jie Yang  4 , Shaowen Huang  4
Affiliations

Influence of nonylphenol and octylphenol exposure on 5-HT, 5-HT transporter, and 5-HT2A receptor

Chunhong Liu et al. Environ Sci Pollut Res Int. 2017 Mar.

Abstract

Nonylphenol (NP) and octylphenol (OP) are priority environmental contaminants that have a potential role as endocrine disruptors. They can be biomagnified in the food chain and pose an estrogenic health risk to human health. A 28-day oral toxicity study was performed to observe the impact of single and combined exposure to NP and OP on 5-HT transporter (SERT) as well as 5-HT2A receptor. Results showed that the 5-HT levels in rat plasma increased with exposure to middle-dose and high-dose NP, to high-dose OP, and to low, middle, and high doses of combined NP and OP (P < 0.05), while the 5-HT levels in rat platelets increased when exposed to NP/OP or combined NP and OP of middle or high dose (P < 0.05). The expression levels of SERT in rat platelets decreased when exposed to high-dose NP/OP or high dose of combined NP and OP (P < 0.05). Meanwhile, the expression levels of 5-HT2A in rat platelets decreased when exposed to high-dose NP/OP as well as combined NP and OP (P < 0.05). These findings suggested that exposure to NP and OP could influence the metabolic network of 5-hydroxytryptamine via transportation and receptor binding pathways.

Keywords: 5-HT2A receptor; 5-Hydroxytryptamine; 5-Hydroxytryptamine transporter; Exposure; Nonylphenol; Octylphenol.

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