Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Meta-Analysis
. 2017 Feb 4;17(1):23.
doi: 10.1186/s12883-017-0795-4.

Meta-analysis on the prevalence of REM sleep behavior disorder symptoms in Parkinson's disease

Jia Zhang  1 , Chuan-Ying Xu  1 , Jun Liu  2
Affiliations
Meta-Analysis

Meta-analysis on the prevalence of REM sleep behavior disorder symptoms in Parkinson's disease

Jia Zhang et al. BMC Neurol. .

Abstract

Background: Our study was aimed to evaluate the risk of a selected non-motor symptom, namely rapid eye movement behavior disorder (RBD) symptoms, among patients with newly diagnosed Parkinson disease compared with health controls.

Methods: The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines for meta-analysis and Cochrane manual were followed. Studies on RBD symptoms and PD were searched using PubMed, Embase, Web of Science and Cochrane library databases. All studies were published before August 3rd, 2016. Eligible studies were those that reported a prevalence of RBD symptoms among newly diagnosed PD and health control. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated by random-effected models. Heterogeneity across studies was assessed using Cochran Q and I2 statistics.

Results: We identified eight studies including 2462 PD patients and 3818 health controls. The overall prevalence of RBD symptoms in PD was 582/2462 (23.6%) compared to 131/3818 (3.4%) in control. And the pooled OR was 5.69 (95% CI 3.60 to 9.00; p = 0.001) with a moderate heterogeneity I2 = 70.5%. After excluding the study of low weight, the overall polled OR was 3.54 (95% CI 2.77 to 4.52; p < 0.00001) and the heterogeneity was completely eliminated (I2 = 0%).

Conclusions: RBD symptoms are common non-motor symptoms of PD, and people with PD are at a higher risk of developing RBD. Further studies are needed to understand the natural history of RBD symptoms in PD and its etiological and clinical implications.

Keywords: Meta-analysis; Non-motor symptoms; Parkinson’s disease; Prevalence; RBD symptoms.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
PRISMA [13] flow chart of literature review and data abstraction
Fig. 2
Fig. 2
Forest plot demonstrating increased RBD risk in those with PD as compared with those control (CI, confidence interval; OR, odds ratio)
Fig. 3
Fig. 3
Funnel plot assessing publication bias in the study of RBD association with PD
See this image and copyright information in PMC

References

    1. Pringsheim T, Jette N, Frolkis A, Steeves TD. The prevalence of Parkinson’s disease: a systematic review and meta-analysis. Mov Disord. 2014;29(13):1583–90. doi: 10.1002/mds.25945. - DOI - PubMed
    1. Postuma RB, Berg D, Stern M, Poewe W, Olanow CW, Oertel W, Obeso J, Marek K, Litvan I, Lang AE, et al. MDS clinical diagnostic criteria for Parkinson’s disease. Mov Disord. 2015;30(12):1591–601. doi: 10.1002/mds.26424. - DOI - PubMed
    1. Postuma RB, Aarsland D, Barone P, Burn DJ, Hawkes CH, Oertel W, Ziemssen T. Identifying prodromal Parkinson’s disease: pre-motor disorders in Parkinson’s disease. Mov Disord. 2012;27(5):617–26. doi: 10.1002/mds.24996. - DOI - PubMed
    1. Schenck CH, Bundlie SR, Ettinger MG, Mahowald MW. Chronic behavioral disorders of human REM sleep: a new category of parasomnia. Sleep. 1986;9(2):293–308. - PubMed
    1. Schenck CH, Bundlie SR, Mahowald MW. Delayed emergence of a parkinsonian disorder in 38% of 29 older men initially diagnosed with idiopathic rapid eye movement sleep behaviour disorder. Neurology. 1996;46(2):388–93. doi: 10.1212/WNL.46.2.388. - DOI - PubMed

Publication types

MeSH terms