Flavonoids from the roots of Artocarpus heterophyllus

Abstract

Four new flavonoids, artoheteroids A-D (1-4), together with six known ones (5-10), were isolated from the roots of Artocarpus heterophyllus. Their structures were elucidated by spectroscopic methods, including 1D and 2D NMR, UV, IR, CD, and HR-ESI-MS. All isolated compounds were screened for their inhibitory abilities against cathepsin K (CatK). Among them, compounds 1-2, 4-6, and 10 were found to have suppression capabilities against CatK with IC₅₀ values ranging from 1.4 to 93.9μM.

Keywords: Artocarpus heterophyllus; Cathepsin K; Isoprenylated flavonoids; Structure elucidation.