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Comment
. 2017 Mar;13(3):137-138.
doi: 10.1038/nrneph.2017.9. Epub 2017 Feb 6.

Acute kidney injury: Acute kidney injury: still misunderstood and misdiagnosed

Prasad Devarajan  1
Affiliations
Comment

Acute kidney injury: Acute kidney injury: still misunderstood and misdiagnosed

Prasad Devarajan. Nat Rev Nephrol. 2017 Mar.

Abstract

New research supports the notion that pre-renal and intrinsic acute kidney injury are distinct molecular entities and hence different disease states despite similar increases in serum creatinine level. Pre-renal AKI induces protective molecular mechanisms whereas intrinsic AKI requires a ‘second hit’ that upregulates injury genes, and results in a persistent elevation of serum creatinine and kidney injury biomarkers.

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Conflict of interest statement

Competing interests statement

P.D. is a co-inventor on patents (7776824 and 7977110) related to NGAL as a biomarker of kidney injury, and declares licensing agreements with BioPorto Diagnostics and Abbott Diagnostics.

Comment on

  • Unique Transcriptional Programs Identify Subtypes of AKI.
    Xu K, Rosenstiel P, Paragas N, Hinze C, Gao X, Huai Shen T, Werth M, Forster C, Deng R, Bruck E, Boles RW, Tornato A, Gopal T, Jones M, Konig J, Stauber J, D'Agati V, Erdjument-Bromage H, Saggi S, Wagener G, Schmidt-Ott KM, Tatonetti N, Tempst P, Oliver JA, Guarnieri P, Barasch J. Xu K, et al. J Am Soc Nephrol. 2017 Jun;28(6):1729-1740. doi: 10.1681/ASN.2016090974. Epub 2016 Dec 27. J Am Soc Nephrol. 2017. PMID: 28028135 Free PMC article.

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