Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 Jan-Jun;7(1):45-51.
doi: 10.4103/0975-5950.196124.

A randomized comparative prospective study of platelet-rich plasma, platelet-rich fibrin, and hydroxyapatite as a graft material for mandibular third molar extraction socket healing

Shubha Ranjan Dutta  1 , Deepak Passi  2 , Purnima Singh  3 , Sarang Sharma  4 , Mahinder Singh  5 , Dhirendra Srivastava  2
Affiliations

A randomized comparative prospective study of platelet-rich plasma, platelet-rich fibrin, and hydroxyapatite as a graft material for mandibular third molar extraction socket healing

Shubha Ranjan Dutta et al. Natl J Maxillofac Surg. 2016 Jan-Jun.

Abstract

Aim: The purpose of this study was to compare the efficacy of platelet-rich plasma (PRP), platelet-rich fibrin (PRF), and hydroxyapatite (HA) for reduction of pain and swelling, absence of dry socket, soft tissue healing, and bone regeneration after mandibular third molar extraction in human patients.

Materials and methods: Forty patients requiring extraction of mandibular third molars were randomly grouped as control, PRP, PRF, and HA-treated. The patients were assessed for postoperative pain, swelling, dry socket, and soft tissue healing on the 3rd, 7th, and 14th day of postoperative periods depending on the standard methods. Radiological assessment of the extraction site was done at 1, 2, and 6 months interval to compare the change in bone density in the sockets in control and treated patients.

Results: Pain and swelling were less on PRP and PRF site when compared to HA and control site. PRP and PRF site showed better soft tissue healing when compared to HA and control site. Radiographic assessment showed comparatively lesser bone density values in PRP, PRF, and control site at 1, 2, and 6 months than HA site.

Conclusion: Our study showed that PRP and PRF are better graft materials than HA regarding pain, swelling, dry socket, and soft tissue healing. Bone regeneration is induced promptly by HA as compared to other graft materials. However, a more elaborate study with a larger number of clinical cases is very much essential to be more conclusive regarding the efficacy of the graft materials.

Keywords: Bone density; hydroxyapatite; mandibular third molar extraction; pain; platelet-rich fibrin; platelet-rich plasma; swelling.

PubMed Disclaimer

Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Representative pictures of pre-, post- and intra-operative periods of surgical extraction of mandibular third molar in control patient
Figure 2
Figure 2
Representative radiographs (intraoral periapical) showing bone healing in control patients
Figure 3
Figure 3
Representative pictures showing pre-, post- and intra-operative periods of surgical extraction of mandibular third molar in platelet-rich plasma-treated patients
Figure 4
Figure 4
Representative radiographs (intraoral periapical) showing bone healing in platelet-rich plasma treated patients
Figure 5
Figure 5
Representative pictures showing pre-, post- and intra-operative periods of surgical extraction of mandibular third molar in protein-rich fibrin-treated patients
Figure 6
Figure 6
Representative radiographs (intraoral periapical) showing bone healing in protein-rich fibrin-treated patients
Figure 7
Figure 7
Representative pictures showing pre-, post- and intra-operative periods of surgical extraction of mandibular third molar in hydroxyapatite-treated patients
Figure 8
Figure 8
Representative radiographs (intraoral periapical) showing bone healing in hydroxyapatite treated patients
Figure 9
Figure 9
Representative picture showing facial swelling measurement by joining the three lines AC, AD, and BE
See this image and copyright information in PMC

References

    1. Aghazadeh A, Rutger Persson G, Renvert S. A single-centre randomized controlled clinical trial on the adjunct treatment of intra-bony defects with autogenous bone or a xenograft: Results after 12 months. J Clin Periodontol. 2012;39:666–73. - PubMed
    1. Meyle J, Hoffmann T, Topoll H, Heinz B, Al-Machot E, Jervøe-Storm PM, et al. A multi-centre randomized controlled clinical trial on the treatment of intra-bony defects with enamel matrix derivatives/synthetic bone graft or enamel matrix derivatives alone: Results after 12 months. J Clin Periodontol. 2011;38:652–60. - PubMed
    1. Misch CM. Autogenous bone: Is it still the gold standard? Implant Dent. 2010;19:361. - PubMed
    1. Ross R, Glomset J, Kariya B, Harker L. A platelet-dependent serum factor that stimulates the proliferation of arterial smooth muscle cells in vitro . Proc Natl Acad Sci U S A. 1974;71:1207–10. - PMC - PubMed
    1. Gassling V, Douglas T, Warnke PH, Açil Y, Wiltfang J, Becker ST. Platelet-rich fibrin membranes as scaffolds for periosteal tissue engineering. Clin Oral Implants Res. 2010;21:543–9. - PubMed