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. 2016 Jan-Jun;7(1):56-61.
doi: 10.4103/0975-5950.196126.

Aerobic microbiology and culture sensitivity of head and neck space infection of odontogenic origin

Amit Shah  1 , Vikas Ramola  2 , Vijay Nautiyal  3
Affiliations

Aerobic microbiology and culture sensitivity of head and neck space infection of odontogenic origin

Amit Shah et al. Natl J Maxillofac Surg. 2016 Jan-Jun.

Abstract

Context: Head and neck space infections source, age, gender, tooth involved, fascial spaces involved, microbiological study of aerobic flora, and antibiotic susceptibilities.

Aims: The aim of the present study is to identify causative aerobic microorganisms responsible for deep fascial spaces of head and neck infections and evaluate the resistance of antibiotics used in the treatment of such.

Settings and design: Prospective study in 100 patients.

Materials and methods: This prospective study was conducted on 100 patients who reported in the outpatient department and fulfilled the inclusion criteria to study aerobic microbiology and antibiotic sensitivity in head and neck space infection of odontogenic origin. Pus sample was obtained either by aspiration or by swab stick from the involved spaces, and culture and sensitivity tests were performed.

Statistical analysis used: Chi-square test and level of significance.

Results: Result showed aerobic Gram-positive isolates were 73% and aerobic Gram-negative isolates were 18%. Nine percent cases showed no growth. Streptococcus viridans was the highest isolate in 47% cases among Gram-positive bacteria, and in Gram-negative, Klebsiella pneumoniae was the highest isolate of total cases 11%. Amoxicillin showed resistance (48.4%) as compared to other antibiotics such as ceftriaxone, carbenicillin, amikacin, and imipenem had significantly higher sensitivity.

Conclusions: Amoxicillin with clavulanic acid showed (64.8%) efficacy for all organisms isolated, whereas ceftriaxone showed (82.4%) efficacy and could be used in odontogenic infections for both Gram-positive and Gram-negative microorganisms. Substitution of third generation cephalosporin for amoxicillin in the empirical management of deep fascial space infections can also be used. Carbenicillin, amikacin, and imipenem showed (93.4%) sensitivity against all microorganisms and should be reserved for more severe infection. Newer and broad-spectrum antibiotics are more effective in vitro than older narrow spectrum antibiotics.

Keywords: Antibiotic resistance; culture and sensitivity; odontogenic infection; orofacial space infections; oromicrobial flora.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Distribution of cases according to age
Figure 2
Figure 2
Distribution of cases according to type of microbial isolate
Figure 3
Figure 3
Relative efficacy of different antibiotics against all microbes
See this image and copyright information in PMC

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References

    1. Robertson D, Smith AJ. The microbiology of the acute dental abscess. J Med Microbiol. 2009;58(Pt 2):155–62. - PubMed
    1. Neu HC. The crisis in antibiotic resistance. Science. 1992;257:1064–73. - PubMed
    1. Storoe W, Haug RH, Lillich TT. The changing face of odontogenic infections. J Oral Maxillofac Surg. 2001;59:739–48. - PubMed
    1. Jacoby GA, Medeirors AA. Beta lactamases in clinical isolates of Klebsiella pneumoniae and Escherichia coli. J Clin Microbiol. 1991;35:1697–704. - PMC - PubMed
    1. Gorbach SL, Gilmore WC, Jacobus NV, Doku HC, Tally FP. Microbiology and antibiotic resistance in odontogenic infections. Ann Otol Rhinol Laryngol Suppl. 1991;154:40–2. - PubMed