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Review
. 2017 Jan 11:6:32.
doi: 10.12688/f1000research.9838.1. eCollection 2017.

STAT5 and CD4 + T Cell Immunity

David L Owen  1 , Michael A Farrar  1
Affiliations
Review

STAT5 and CD4 + T Cell Immunity

David L Owen et al. F1000Res. .

Abstract

STAT5 plays a critical role in the development and function of many cell types. Here, we review the role of STAT5 in the development of T lymphocytes in the thymus and its subsequent role in the differentiation of distinct CD4 + helper and regulatory T-cell subsets.

Keywords: STAT5; T-cell development; T-cell function.

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Conflict of interest statement

The authors declare that they have no competing interests. No competing interests were disclosed. No competing interests were disclosed. No competing interests were disclosed. No competing interests were disclosed. No competing interests were disclosed.

Figures

Figure 1.
Figure 1.. Model outlining how STAT5 activation (pSTAT5) contributes to the differentiation of naïve CD4 T cells into various T helper (TH) subsets.
In TH1 development, STAT5 drives interleukin 12 receptor beta 2 subunit (IL12Rβ2) expression. For TH2, STAT5 drives upregulation of IL4Rα. For TH9, STAT5 activation is required for IL9 production. In T helper type granulocyte-macrophage colony-stimulating factor (TH GM), STAT5 is critical for granulocyte-macrophage colony-stimulating factor (GM-CSF) production. STAT5 opposes the activation of STAT3, which is required for TH17 differentiation. STAT5 downregulates Bcl6 expression to inhibit T follicular helper (TFH) cell differentiation, and in regulatory T cells STAT5 turns on Foxp3 as well as CD25.
Figure 2.
Figure 2.. Model outlining the roles STAT5 plays in T regulatory biology in both the thymus and the periphery.
STAT5 activation (pSTAT5) is required to complete the differentiation of thymic regulatory T (tTreg) cells and initiate the differentiation of peripherally induced regulatory T (pTreg) cells. STAT5 is also critical for the maintenance of Foxp3 expression, via binding the Cns2 regulatory region in Foxp3, and the suppressor phenotype of regulatory T cells.
See this image and copyright information in PMC

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