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Review
. 2017;14(11):1190-1197.
doi: 10.2174/1567205014666170203141151.

Commonalities in Biological Pathways, Genetics, and Cellular Mechanism between Alzheimer Disease and Other Neurodegenerative Diseases: An In Silico-Updated Overview

Khurshid Ahmad  1 , Mohammad Hassan Baig  2 , Gohar Mushtaq  3 , Mohammad Amjad Kamal  4 , Nigel H Greig  5 , Inho Choi  2
Affiliations
Review

Commonalities in Biological Pathways, Genetics, and Cellular Mechanism between Alzheimer Disease and Other Neurodegenerative Diseases: An In Silico-Updated Overview

Khurshid Ahmad et al. Curr Alzheimer Res. 2017.

Abstract

Background: Alzheimer's disease (AD) is the most common and well-studied neurodegenerative disease (ND). Biological pathways, pathophysiology and genetics of AD show commonalities with other NDs viz. Parkinson's disease (PD), Amyotrophic lateral sclerosis (ALS), Huntington's disease (HD), Prion disease and Dentatorubral-pallidoluysian atrophy (DRPLA). Many of the NDs, sharing the common features and molecular mechanisms suggest that pathology may be directly comparable and be implicated in disease prevention and development of highly effective therapies.

Method: In this review, a brief description of pathophysiology, clinical symptoms and available treatment of various NDs have been explored with special emphasis on AD. Commonalities in these fatal NDs provide support for therapeutic advancements and enhance the understanding of disease manifestation.

Conclusion: The studies concentrating on the commonalities in biological pathways, cellular mechanisms and genetics may provide the scope to researchers to identify few novel common target(s) for disease prevention and development of effective common drugs for multi-neurodegenerative diseases.

Keywords: Alzheimer disease; Amyotrophic lateral sclerosis; Huntington's disease; Neurodegenerative diseases; Parkinson's disease; biological pathways.

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Conflict of interest statement

CONFLICT OF INTEREST

The authors declare no conflict of interest, financial or otherwise.

Figures

Fig. (1)
Fig. (1)
APP processing by secretase enzymes.
Fig. (2)
Fig. (2)
Schematic comparison between normal and Parkinson’s disease.
See this image and copyright information in PMC

References

    1. Silberberg D. The high impact of neurologic disorders in developing countries: the struggle for global recognition. Neurology. 2011;77(3):307–8. - PubMed
    1. Pedro AV. Coping with Brain Disorders using Neurotechnology. Malays J Med Sci. 2012;19(1):1–3. - PMC - PubMed
    1. Teplow DB. Molecular biology of neurodegenerative diseases. Preface Prog Mol Biol Transl Sci. 2012;107:xiii–xiv. - PubMed
    1. Gao HM, Hong JS. Why neurodegenerative diseases are progressive: uncontrolled inflammation drives disease progression. Trends Immunol. 2008;29(8):357–65. - PMC - PubMed
    1. Kruttgen A, Saxena S, Evangelopoulos ME, Weis J. Neurotrophins and neurodegenerative diseases: receptors stuck in traffic? J Neuropathol Exp Neurol. 2003;62(4):340–50. - PubMed

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