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. 2017 Mar;17(3):206-208.
doi: 10.1089/vbz.2016.2007. Epub 2017 Feb 6.

Acute and Late Bartonella henselae Murine Model Infection

Marilene Neves da Silva  1 , Gislaine Vieira-Damiani  1   2 , Marna Elise Ericson  3 , Kalpna Gupta  4 , Amanda Roberta de Almeida  1 , Marina Rovani Drummond  1 , Tania Cristina Benetti Soares  1 , Bruno Grosselli Lania  1 , Rovilson Gilioli  5 , Paulo Eduardo Neves Ferreira Velho  1
Affiliations

Acute and Late Bartonella henselae Murine Model Infection

Marilene Neves da Silva et al. Vector Borne Zoonotic Dis. 2017 Mar.

Abstract

Bartonella spp. are fastidious gram-negative neglected bacilli with worldwide distribution. They are able to cause intraerythrocytic and potentially fatal infection. Cats and dogs are reservoirs of some species of these agents. Blood-sucking arthropods are potential vectors. Our aim was to evaluate the blood, skin, liver, and spleen in BALB/c mice by using molecular tests and confocal microscopy to demonstrate Bartonella henselae infection in the bloodstream and organs after 4 and 21 days of intraperitoneally injected bacterial suspension. We demonstrate that the occurrence of infection in organs precedes the detectable infection in blood. Therefore, late manifestation in blood may be another challenge in early detection and diagnosis of B. henselae infection.

Keywords: Bartonella; diagnosis; vector-borne; zoonotic.

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Conflict of interest statement

No competing financial interests exist.

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