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. 2017 Apr;96(4):856-862.
doi: 10.4269/ajtmh.16-0897. Epub 2017 Feb 6.

Schistosomiasis and Human Immunodeficiency Virus in Men in Tanzania

Jennifer A Downs  1   2 , Claudia J de Dood  3 , Hannah E Dee  2 , Megan McGeehan  2 , Hijab Khan  4 , Abena Marenga  4 , Patrick E Adel  5 , Edward Faustine  5 , Benson Issarow  5 , Emmanuel F Kisanga  5 , Godfrey Alfred Kisigo  5 , Salvius Ngahyolerwa  5 , Frank Zahoro  5 , Donald Miyaye  6 , Ruth Gideon Magawa  6 , Julius Mngara  6 , Myung Hee Lee  2 , Paul L A M Corstjens  3 , Govert J van Dam  7 , Daniel W Fitzgerald  2
Affiliations

Schistosomiasis and Human Immunodeficiency Virus in Men in Tanzania

Jennifer A Downs et al. Am J Trop Med Hyg. 2017 Apr.

Abstract

AbstractSchistosomiasis is a parasitic worm infection that affects over 260 million individuals worldwide. Women with schistosome infections have been demonstrated to have a 4-fold increase in the odds of human immunodeficiency virus (HIV) infection compared with women without schistosome infections. A relationship between schistosome and HIV infections has not been clearly defined in men. Among 674 men aged 18-50 years living in rural Tanzania, we identified 429 (63.6%) who had a schistosome infection as defined by serum positivity for schistosome circulating anodic antigen, visualization of parasite eggs in urine or stool, or both. HIV infection was identified in 38 (5.6%). The odds of HIV infection was 1.3 [95% confidence interval = 0.6-2.5] (P = 0.53) among men with any schistosome infection (Schistosoma haematobium or Schistosoma mansoni), and it was 1.4 [0.6-3.3] (P = 0.43) among men with S. haematobium infection. Men with S. haematobium infection were significantly more likely to report the symptom of hemospermia than men without S. haematobium infection. We conclude that schistosome infections appear to have little to no association with HIV infection in men.

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Figures

Figure 1.
Figure 1.
Map of study sites and prevalence of schistosome infections in the Lake Victoria region of northwest Tanzania. Villages noted in blue are endemic for Schistosoma mansoni, and villages shown in red are endemic for Schistosoma haematobium.
See this image and copyright information in PMC

References

    1. World Health Organization chistosomiasis Fact Sheet No 115. 2016. http://www.who.int/topics/schistosomiasis/en/ Available at. Accessed May 8, 2016.
    1. Downs JA, Mguta C, Kaatano GM, Mitchell KB, Bang H, Simplice H, Kalluvya SE, Changalucha JM, Johnson WD, Jr, Fitzgerald DW. Urogenital schistosomiasis in women of reproductive age in Tanzania's Lake Victoria region. Am J Trop Med Hyg. 2011;84:364–369. - PMC - PubMed
    1. Kjetland EF, Ndhlovu PD, Gomo E, Mduluza T, Midzi N, Gwanzura L, Mason PR, Sandvik L, Friis H, Gundersen SG. Association between genital schistosomiasis and HIV in rural Zimbabwean women. AIDS. 2006;20:593–600. - PubMed
    1. Downs JA, van Dam GJ, Changalucha JM, Corstjens PL, Peck RN, de Dood CJ, Bang H, Andreasen A, Kalluvya SE, van Lieshout L, Johnson WD, Jr, Fitzgerald DW. Association of schistosomiasis and HIV infection in Tanzania. Am J Trop Med Hyg. 2012;87:868–873. - PMC - PubMed
    1. Mazigo HD, Dunne DW, Wilson S, Kinung'hi SM, Pinot de Moira A, Jones FM, Morona D, Nuwaha F. Co-infection with Schistosoma mansoni and human immunodeficiency virus-1 (HIV-1) among residents of fishing villages of north-western Tanzania. Parasit Vectors. 2014;7:587. - PMC - PubMed