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Comment
. 2017 Feb;7(2):128-130.
doi: 10.1158/2159-8290.CD-16-1439.

JAK Mutations as Escape Mechanisms to Anti-PD-1 Therapy

Aurelien Marabelle  1   2 , Sandrine Aspeslagh  1 , Sophie Postel-Vinay  1   3 , Jean-Charles Soria  4   3
Affiliations
Comment

JAK Mutations as Escape Mechanisms to Anti-PD-1 Therapy

Aurelien Marabelle et al. Cancer Discov. 2017 Feb.

Abstract

JAK mutations could be one of the primary escape mechanisms to anti-PD-1/PD-L1 immunotherapy via impaired IFNγ signaling in cancer cells and could be used to identify patients unlikely to benefit from these treatments. Cancer Discov; 7(2); 128-30. ©2017 AACR.See related article by Shin et al., p. 188.

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  • Primary Resistance to PD-1 Blockade Mediated by JAK1/2 Mutations.
    Shin DS, Zaretsky JM, Escuin-Ordinas H, Garcia-Diaz A, Hu-Lieskovan S, Kalbasi A, Grasso CS, Hugo W, Sandoval S, Torrejon DY, Palaskas N, Rodriguez GA, Parisi G, Azhdam A, Chmielowski B, Cherry G, Seja E, Berent-Maoz B, Shintaku IP, Le DT, Pardoll DM, Diaz LA Jr, Tumeh PC, Graeber TG, Lo RS, Comin-Anduix B, Ribas A. Shin DS, et al. Cancer Discov. 2017 Feb;7(2):188-201. doi: 10.1158/2159-8290.CD-16-1223. Epub 2016 Nov 30. Cancer Discov. 2017. PMID: 27903500 Free PMC article.

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