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. 2016 Dec;57(4):E205-E210.

Relationship between lead exposure and mild cognitive impairment

C Fenga  1 , S Gangemi  1 , A Alibrandi  2 , C Costa  3 , E Micali  4
Affiliations

Relationship between lead exposure and mild cognitive impairment

C Fenga et al. J Prev Med Hyg. 2016 Dec.

Abstract

Introduction: Since it is still controversial whether-low-to moderate long-term lead below current threshold values causes neurobehavioural deficits in adults.

Methods: Forty lead-exposed workers subjects with a mean blood lead (PbB) level of 56.4 μg/dL and 40 non-lead-exposed aged matched subjects (PbB: 15.4 μg/dL) with the same socio-economic background were investigated. Participants were administered a neuropsychological tests consisting of BAMT (Branches Alternate Movements Task), FT (Finger Tapping Speed), DS (Digit Span) POMS (Profile of Mood States).

Results: Authors noted a significant relationship between the exposed and the referent groups in tests mainly involving executive functions, short time memory and psycho-emotional variables. In addition, Poisson regression test performed on single psychoemotional factors (POMS), has allowed to evidence a significant influence of Pb e ZPP levels on tension, anxiety and depression.

Conclusions: The present study showed that lead exposure among adults at levels previously considered safe, results in impairment of certain cognitive abilities.

Keywords: ALAD; Lead exposed workers blood lead level; Low lead exposure; Neurobehavioral effects; ZPP.

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