Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2017 Jan 24:7:150.
doi: 10.3389/fendo.2016.00150. eCollection 2016.

Autoimmune/Inflammatory Syndrome Induced by Adjuvants and Thyroid Autoimmunity

Abdulla Watad  1 , Paula David  2 , Stav Brown  3 , Yehuda Shoenfeld  4
Affiliations
Review

Autoimmune/Inflammatory Syndrome Induced by Adjuvants and Thyroid Autoimmunity

Abdulla Watad et al. Front Endocrinol (Lausanne). .

Abstract

The autoimmune/inflammatory syndrome induced by adjuvants (ASIA), presented by Shoenfeld and Agmon-Levin in 2011, is an entity that incorporates diverse autoimmune conditions induced by the exposure to various adjuvants. Adjuvants are agents that entail the capability to induce immune reactions. Adjuvants are found in many vaccines and used mainly to increase the response to vaccination in the general population. Silicone has also been reported to be able to induce diverse immune reactions. Clinical cases and series of heterogeneous autoimmune conditions including systemic sclerosis, systemic lupus erythematosus, and rheumatoid arthritis have been reported to be induced by several adjuvants. However, only a small number of cases of autoimmune thyroid disorder have been included under the umbrella of ASIA syndrome. Indeed, clinical cases of Hashimoto's thyroiditis and/or subacute thyroiditis were observed after the exposure to vaccines as well as silicone implantation. In our review, we aimed to summarize the current knowledge on ASIA syndrome presented as endocrinopathies, focusing on autoimmune thyroid disorders associated with the various adjuvants.

Keywords: Graves disease; Hashimoto’s thyroiditis; adjuvants; autoimmune/inflammatory syndrome induced by adjuvants; endocrinopathy; silicone; thyroid; vaccines.

PubMed Disclaimer

References

    1. Perricone C, Colafrancesco S, Mazor RD, Soriano A, Agmon-Levin N, Shoenfeld Y. Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) 2013: unveiling the pathogenic, clinical and diagnostic aspects. J Autoimmun (2013) 47:1–16.10.1016/j.jaut.2013.10.004 - DOI - PubMed
    1. Vera-Lastra O, Medina G, Cruz-Dominguez MDP, Ramirez P, Gayosso-Rivera JA, Anduaga-Dominguez H, et al. Human adjuvant disease induced by foreign substances: a new model of ASIA (Shoenfeld’s syndrome). Lupus (2012) 21:128–35.10.1177/0961203311429317 - DOI - PubMed
    1. Meroni PL. Autoimmune or auto-inflammatory syndrome induced by adjuvants (ASIA): old truths and a new syndrome? J Autoimmun (2011) 36:1–3.10.1016/j.jaut.2010.10.004 - DOI - PubMed
    1. Jara LJ, García-Collinot G, Medina G, Cruz-Dominguez MD, Vera-Lastra O, Carranza-Muleiro RA, et al. Severe manifestations of autoimmune syndrome induced by adjuvants (Shoenfeld’s syndrome). Immunol Res (2016).10.1007/s12026-016-8811-0 - DOI - PubMed
    1. Israeli E, Pardo A. The sick building syndrome as a part of the autoimmune (auto-inflammatory) syndrome induced by adjuvants. Mod Rheumatol (2011) 21:235–9.10.1007/s10165-010-0380-9 - DOI - PubMed