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. 2017 Jun 1;123(11):2014-2024.
doi: 10.1002/cncr.30561. Epub 2017 Feb 7.

The American Cancer Society's Cancer Prevention Study 3 (CPS-3): Recruitment, study design, and baseline characteristics

Alpa V Patel  1 , Eric J Jacobs  1 , Daniela M Dudas  1 , Peter J Briggs  1 , Cari J Lichtman  1 , Elizabeth B Bain  1 , Victoria L Stevens  1 , Marjorie L McCullough  1 , Lauren R Teras  1 , Peter T Campbell  1 , Mia M Gaudet  1 , Elizabeth G Kirkland  1 , Melissa H Rittase  1 , Nance Joiner  1 , W Ryan Diver  1 , Janet S Hildebrand  1 , Nancy C Yaw  2 , Susan M Gapstur  1
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Free article

The American Cancer Society's Cancer Prevention Study 3 (CPS-3): Recruitment, study design, and baseline characteristics

Alpa V Patel et al. Cancer. .
Free article

Abstract

Background: Prospective cohort studies contribute importantly to understanding the role of lifestyle, genetic, and other factors in chronic disease etiology.

Methods: The American Cancer Society (ACS) recruited a new prospective cohort study, Cancer Prevention Study 3 (CPS-3), between 2006 and 2013 from 35 states and Puerto Rico. Enrollment took place primarily at ACS community events and at community enrollment "drives." At enrollment sites, participants completed a brief survey that included an informed consent, identifying information necessary for follow-up, and key exposure information. They also provided a waist measure and a nonfasting blood sample. Most participants also completed a more comprehensive baseline survey at home that included extensive medical, lifestyle, and other information. Participants will be followed for incident cancers through linkage with state cancer registries and for cause-specific mortality through linkage with the National Death Index.

Results: In total, 303,682 participants were enrolled. Of these, 254,650 completed the baseline survey and are considered "fully" enrolled; they will be sent repeat surveys periodically for at least the next 20 years to update exposure information. The remaining participants (n = 49,032) will not be asked to update exposure information but will be followed for outcomes. Twenty-three percent of participants were men, 17.3% reported a race or ethnicity other than "white," and the median age at enrollment was 47 years.

Conclusions: CPS-3 will be a valuable resource for studies of cancer and other outcomes because of its size; its diversity with respect to age, ethnicity, and geography; and the availability of blood samples and detailed questionnaire information collected over time. Cancer 2017;123:2014-2024. © 2017 American Cancer Society.

Keywords: Cancer Prevention Study; epidemiology; prospective cohort; recruitment; study design.

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