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. 2017 Apr:37:72-78.
doi: 10.1016/j.parkreldis.2017.01.017. Epub 2017 Feb 1.

Personality and addictive behaviours in early Parkinson's disease and REM sleep behaviour disorder

Fahd Baig  1 , Michael A Lawton  2 , Michal Rolinski  1 , Claudio Ruffmann  1 , Johannes C Klein  1 , Kannan Nithi  3 , David Okai  4 , Yoav Ben-Shlomo  5 , Michele T M Hu  6
Affiliations

Personality and addictive behaviours in early Parkinson's disease and REM sleep behaviour disorder

Fahd Baig et al. Parkinsonism Relat Disord. 2017 Apr.

Abstract

Introduction: Changes in personality have been described in Parkinson's disease (PD), with suggestion that those with established disease tend to be risk averse with a disinclination for addictive behaviour. However, little is known about the earliest and prodromal stages. Personality and its relationship with addictive behaviours can help answer important questions about the mechanisms underlying PD and addiction.

Methods: 941 population-ascertained PD subjects within 3.5 years of diagnosis, 128 patients with rapid eye movement sleep behaviour disorder (RBD) and 292 control subjects were fully characterised for motor symptoms, non-motor symptoms and across the following 5 personality domains: 1) neuroticism 2) extraversion 3) conscientiousness 4) agreeableness 5) openness using the Big Five Inventory.

Results: Patients with early PD were more neurotic (p < 0.001), less extraverted (p < 0.001) and less open than controls (p < 0.001). RBD subjects showed the same pattern of being more neurotic (p < 0.001), less extraverted (p = 0.03) and less open (p < 0.001). PD patients had smoked less (p = 0.02) and drunk less alcohol (p = 0.03) than controls, but caffeine beverage consumption was similar. Being more extraverted (p < 0.001), more open (p < 0.001), and less neurotic (p < 0.001) predicted higher alcohol use, while being more extravert (p = 0.007) and less agreeable (p < 0.001) was associated with smoking more.

Conclusions: A similar pattern of personality changes is seen in PD and RBD compared to a control population. Personality characteristics were associated with addictive behaviours, suggestive of a common link, but the lower rates of addictive behaviours before and after the onset of motor symptoms in PD persisted after accounting for personality.

Keywords: Addiction; Parkinson's disease; Personality; REM sleep behaviour disorder; Smoking.

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Figures

Fig. 1
Fig. 1
Flow chart of participant inclusion and exclusion.
See this image and copyright information in PMC

References

    1. Todes C.J., Lees A.J. The pre-morbid personality of patients with Parkinson's disease. J. Neurol. Neurosurg. Psychiatr. 1985;48(2):97–100. - PMC - PubMed
    1. Poletti M., Bonuccelli U. Personality traits in patients with Parkinson's disease: assessment and clinical implications. J. Neurol. 2012;259(6):1029–1038. - PubMed
    1. Evans A.H., Lawrence A.D., Potts J., MacGregor L., Katzenschlager R., Shaw K., Zijlmans J., Lees A.J. Relationship between impulsive sensation seeking traits, smoking, alcohol and caffeine intake, and Parkinson's disease. J. Neurol. Neurosurg. Psychiatr. 2006;77(3):317–321. - PMC - PubMed
    1. Hernan M.A., Takkouche B., Caamano-Isorna F., Gestal-Otero J.J. A meta-analysis of coffee drinking, cigarette smoking, and the risk of Parkinson's disease. Ann. Neurol. 2002;52(3):276–284. - PubMed
    1. Zhang D., Jiang H., Xie J. Alcohol intake and risk of Parkinson's disease: a MetaAnalysis of observational studies. Mov. Disord. 2014;29(6):819–822. - PubMed

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