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Comment
. 2017 Mar;23(3):197-200.
doi: 10.1016/j.molmed.2017.01.008. Epub 2017 Feb 5.

Targeting PFKFB3 in the Endothelium for Cancer Therapy

Qi Yang  1 , Peng Hou  2
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Targeting PFKFB3 in the Endothelium for Cancer Therapy

Qi Yang et al. Trends Mol Med. 2017 Mar.

Abstract

In a recent article published in Cancer Cell, Cantelmo et al. showed that inhibition of endothelium glycolysis by targeting 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3) significantly impaired tumor metastasis by normalizing tumor vessels. In addition, as a promising therapeutic strategy, tumor vessel normalization by PFKFB3 blockade also improved the delivery and efficacy of chemotherapy.

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