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. 2000 Jan;439(Suppl 1):r040-r041.
doi: 10.1007/s004240000084.

Deletion/insertion polymorphism in the angiotension - converting enzyme gene as a risk factor in the Slovenian patients with coronary heart disease

Borut Peterlin  1 , Daniel Petrovič  1 , Metka Zorc  2 , Irena Keber  3
Affiliations

Deletion/insertion polymorphism in the angiotension - converting enzyme gene as a risk factor in the Slovenian patients with coronary heart disease

Borut Peterlin et al. Pflugers Arch. 2000 Jan.

Abstract

The angiotensin-converting enzyme (ACE) plays by degradation of angiotensin I and bradykinin, an important role in modulations of smooth muscle proliferation and vascular tone. Typical plasma levels of ACE accompany the I/D polymorphism; however, a controversy exists as to whether the DD genotype of the ACE polymorphism affects the risk for the development of coronary heart disease (CHD). We compared the I/D polymorphism in 171 Slovenian CHD patients that were younger man 55 years with 134 healthy control individuals. The DD genotype is associated with a 2.3 - fold increase in the risk for CHD.

Keywords: Key words: angiotensin-converting enzyme; coronary heart disease; genetic polymorphism; risk factor.

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