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. 2017 Feb 7;18(2):348.
doi: 10.3390/ijms18020348.

Perindopril Induces TSP-1 Expression in Hypertensive Patients with Endothelial Dysfunction in Chronic Treatment

Valentina Buda  1 , Minodora Andor  2 , Lucian Petrescu  3 , Carmen Cristescu  4 , Dana Emilia Baibata  5 , Mirela Voicu  6 , Melania Munteanu  7 , Ioana Citu  8 , Calin Muntean  9 , Octavian Cretu  10 , Mirela Cleopatra Tomescu  11
Affiliations

Perindopril Induces TSP-1 Expression in Hypertensive Patients with Endothelial Dysfunction in Chronic Treatment

Valentina Buda et al. Int J Mol Sci. .

Abstract

Thrombospondin-1 (TSP-1) is a potent endogenous inhibitor of both physiological and pathological angiogenesis, widely studied as a target in drug development for treating cancer. Several studies performed in the cardiovascular field on TSP-1 are contradictory, the role of TSP-1 in the physiopathology of cardiovascular disorders (CVDs) being, for the moment, incompletely understood and may be due to the presence of several domains in its structure which can stimulate many cellular receptors. It has been reported to inhibit NO-mediated signaling and to act on the angiogenesis, tissue perfusion, endothelial cell proliferation, and homeostasis, so we aimed to quantify the effect Perindopril has on TSP-1 plasma levels in hypertensive patients with endothelial dysfunction in comparison with other antihypertensive drugs, such as beta blockers, calcium channel blockers, and diuretics, in a chronic treatment. As a conclusion, patients under treatment with Perindopril had increased plasma levels of TSP-1 compared with other hypertensive patients and with the control group. The results of this study confirms the pleiotropic properties of Perindopril: anti-proliferative, anti-inflammatory, with effects showed by quantifying a single biomarker: TSP-1.

Keywords: TSP-1; angiotensin-converting enzyme (ACE) inhibitors; anti-inflammatory; anti-proliferative; antihypertensive drugs; endothelial dysfunction; essential arterial hypertension; perindopril; thrombospondin-1.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Variation of TSP-1 plasma levels in Group C, under different concentrations of Perindopril.
Figure 2
Figure 2
Variation of TSP-1 plasma levels in men and women in Group C.
Figure 3
Figure 3
Variation of TSP-1 plasma levels in Group B, under different antihypertensive treatment: (a) beta blockers, (b) calcium channel blockers, and (c) diuretics.
Figure 3
Figure 3
Variation of TSP-1 plasma levels in Group B, under different antihypertensive treatment: (a) beta blockers, (b) calcium channel blockers, and (c) diuretics.
See this image and copyright information in PMC

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