Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2017 Feb 8;35(2):125-126.
doi: 10.1038/nbt.3786.

Exploring protein sequence-function landscapes

Tyler N Starr  1 , Joseph W Thornton  2
Affiliations
Comment

Exploring protein sequence-function landscapes

Tyler N Starr et al. Nat Biotechnol. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

COMPETING FINANCIAL INTERESTS

The authors declare no competing financial interests.

Figures

Figure 1
Figure 1
Origins of covariation in a multiple sequence alignment. (a) Sequence sites that are physically adjacent in a three-dimensional protein structure (red and purple, and purple and blue) mutually constrain each other’s set of tolerable amino acid states. (b) These interactions leave signatures of covariation in a multiple sequence alignment. But covariation can also occur between sites that do not interact (red and blue) because they are transitively coupled with a third site (purple). Rows represent protein sequences, whose evolutionary relationships are represented in the cladogram at left.
See this image and copyright information in PMC

Comment on

  • Mutation effects predicted from sequence co-variation.
    Hopf TA, Ingraham JB, Poelwijk FJ, Schärfe CP, Springer M, Sander C, Marks DS. Hopf TA, et al. Nat Biotechnol. 2017 Feb;35(2):128-135. doi: 10.1038/nbt.3769. Epub 2017 Jan 16. Nat Biotechnol. 2017. PMID: 28092658 Free PMC article.

References

    1. Fowler DM & Fields S Nat. Methods 11, 801–807 (2014). - PMC - PubMed
    1. Hopf TA et al. Nat. Biotechnol. 35, 128–135 (2017). - PMC - PubMed
    1. Ng PC & Henikoff S Annu. Rev. Genomics Hum. Genet. 7, 61–80 (2006). - PubMed
    1. Starr TN & Thornton JW Protein Sci. 25, 1204–1218 (2016). - PMC - PubMed
    1. Kondrashov AS, Sunyaev S & Kondrashov FA Proc. Natl. Acad. Sci. USA 99, 14878–14883 (2002). - PMC - PubMed

Publication types

LinkOut - more resources