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Comment
. 2017 Feb 7;25(2):225-226.
doi: 10.1016/j.cmet.2017.01.015.

The Hunger Games: Salmonella, Anorexia, and NLRP3

Luke A J O'Neill  1
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The Hunger Games: Salmonella, Anorexia, and NLRP3

Luke A J O'Neill. Cell Metab. .
Free article

Abstract

Rao and colleagues (2017) reveal how Salmonella limits anorexia in mice, protecting them and promoting the spread of infection. The mechanism involves inhibition of the NLRP3 inflammasome limiting vagal nerve stimulation by IL-1β, which in turn promotes appetite. A possible new therapeutic approach for treating anorexia in multiple diseases is proposed.

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