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Comment
. 2017 Feb 21;114(8):1765-1767.
doi: 10.1073/pnas.1620579114. Epub 2017 Feb 8.

Deconstructing mammalian thermoregulation

Wolfgang B Liedtke  1   2   3
Affiliations
Comment

Deconstructing mammalian thermoregulation

Wolfgang B Liedtke. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The author declares no conflict of interest.

Figures

Fig. 1.
Fig. 1.
Schematic shows a rise in temperature activating the warm-responsive, GABAergic neurons in the vLPO subnucleus of the preoptic area (POA), illustrated for schematic orientation in the mouse brain above. These GABAergic neurons relay synaptically to GABAergic and also to glutamate-ergic neurons in the DMD subnucleus of the dorsomedial hypothalamic (DMH) nucleus, schematically also shown above. GABAergic relay (i.e., inhibitory neurotransmission) to both types of DMD neurons attenuates thermogenesis, metabolic rate, and also behavioral motor activity, presumably via efferences to the rostral pallidum (RPa) in the brainstem. Note that GABAergic vLPO neurons could be intrinsically warm-sensitive, as well as receive warmth-evoked peripheral afferences.
See this image and copyright information in PMC

Comment on

  • A hypothalamic circuit that controls body temperature.
    Zhao ZD, Yang WZ, Gao C, Fu X, Zhang W, Zhou Q, Chen W, Ni X, Lin JK, Yang J, Xu XH, Shen WL. Zhao ZD, et al. Proc Natl Acad Sci U S A. 2017 Feb 21;114(8):2042-2047. doi: 10.1073/pnas.1616255114. Epub 2017 Jan 4. Proc Natl Acad Sci U S A. 2017. PMID: 28053227 Free PMC article.

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