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Case Reports
. 2017 Mar;9(3):213-215.
doi: 10.14740/jocmr2929w. Epub 2017 Jan 25.

Composite Lymphoma: Opposite Ends of Spectrum Meet

Uqba Khan  1 , Tarik Hadid  1 , Warda Ibrar  1 , Dahlia Sano  1 , Ayad Al-Katib  1
Affiliations
Case Reports

Composite Lymphoma: Opposite Ends of Spectrum Meet

Uqba Khan et al. J Clin Med Res. 2017 Mar.

Abstract

An 18-year-old African-American female presented with an episode of syncope. Initial investigations revealed large lung mass with invasion into right atrium along with lesions in kidneys and liver. Patient also developed superior vena cava syndrome due to lung mass. Biopsy of lung mass revealed diagnosis of composite lymphoma with involvement by primary mediastinal B-cell lymphoma (PMBCL) and classical Hodgkin lymphoma. Patient was started on dose-adjusted etoposide, prednisone, vincristine, cyclophosphamide, doxorubicin and rituximab (EPOCH-R) with complete response to treatment. This case represents an extremely rare type of aggressive lymphoma and can guide clinicians in managing such cases since there are no standard guidelines for treatment. To the best of our knowledge, this is the first reported case of composite lymphoma of PMBCL and classical Hodgkin lymphoma successfully treated with dose-adjusted EPOCH-R regimen.

Keywords: Composite lymphoma; EPOCH-R; Primary mediastinal B-cell lymphoma.

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Figures

Figure 1
Figure 1
Pathological comparison of PMBCL and Hodgkin lymphoma on biopsy specimen.
See this image and copyright information in PMC

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