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. 2017 Feb;78(1):37-42.
doi: 10.1055/s-0036-1584310. Epub 2016 Jun 10.

Update on Surgical Outcomes of Lateral Temporal Bone Resection for Ear and Temporal Bone Malignancies

Sumi Sinha  1 , Matthew M Dedmon  1 , Matthew R Naunheim  1 , Jennifer C Fuller  1 , Stacey T Gray  1 , Derrick T Lin  1
Affiliations

Update on Surgical Outcomes of Lateral Temporal Bone Resection for Ear and Temporal Bone Malignancies

Sumi Sinha et al. J Neurol Surg B Skull Base. 2017 Feb.

Abstract

Objectives Review outcomes of lateral temporal bone resections for ear and temporal bone malignancy. Design, Setting, and Participants Retrospective review of all lateral temporal bone resections performed from 2008 to 2015 at a single tertiary care center. Main Outcome Measures Patient demographics, perioperative variables, overall survival, disease-free survival (DFS), and comparison of Kaplan-Meier curves. Results Overall, 56 patients were identified with a mean follow-up period of 2.3 ± 1.8 years. The predominant histopathologic diagnosis was squamous cell carcinoma (SCC, 54%), followed by salivary gland tumors (18%), and basal cell carcinoma (9%). Tumor stages were T1-T2 in 23%, T3-T4 in 73%, and two unknown primary lesions. Mean overall survival was 4.6 ± 0.4 years. Comparison of tumors with and without lymph node involvement or perineural invasion approached statistical significance for overall survival (p = 0.07 and 0.06, respectively). DFS was 2.5 ± 0.3 years. Stratification by lymph node status had a statistically significant difference in DFS (p = 0.03). Subgroup analysis of SCC patients did not reveal significant differences. Conclusions Based on our cohort, most patients with temporal bone malignancies present with advanced disease, making it difficult to achieve negative margins. Overall, lymph node status was the strongest predictor of survival in this group.

Keywords: cancer; lateral temporal bone resection; malignancy; outcomes.

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Conflict of interest statement

Funding Sources None. Conflicts of Interest None.

Figures

Fig. 1
Fig. 1
Histogram depiction of cases per year demonstrating the frequency of LTBR surgeries during the study period. LTBR, lateral temporal bone resection.
Fig. 2
Fig. 2
Stratification of overall survival by (A) early versus advanced tumor stage (p = 0.28) (B) negative versus positive pathological margins after surgery (p = 0.42) (C) negative versus positive lymph node status diagnosed after surgery (p = 0.07) and (D) negative versus positive perineural invasion (p = 0.06).
Fig. 3
Fig. 3
Stratification of disease-free survival by (A) early versus advanced tumor stage (p = 0.06) (B) margin status (p = 0.55) (C) negative versus positive lymph node status diagnosed after surgery (p = 0.03) and (D) negative versus positive perineural invasion (p = 0.09).
See this image and copyright information in PMC

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