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Case Reports
. 2017 Jan;78(1):e9-e11.
doi: 10.1055/s-0036-1597599.

Anterior Skull Base Glomangioma-Induced Osteomalacia

Malia S Gresham  1 , Steven Shen  2 , Yi J Zhang  3 , Kelly Gallagher  1
Affiliations
Case Reports

Anterior Skull Base Glomangioma-Induced Osteomalacia

Malia S Gresham et al. J Neurol Surg Rep. 2017 Jan.

Abstract

Oncogenic osteomalacia (OO) is an uncommon but treatable cause of osteomalacia related to tumor production of FGF23, usually caused by benign mesenchymal neoplasms. Paranasal sinus glomangiomas are a rare cause of OO, with only one previously reported case. Here we describe a second case (first reported in English) of paranasal sinus glomangioma-induced osteomalacia in a 42-year-old man. He presented with weakness and multiple spontaneous fractures, and was found to have an ethmoid sinus glomangioma with intracranial extension. The tumor was removed via endoscopic endonasal approach to the anterior skull base, which resulted in complete resolution of symptoms and no further evidence of disease 1 year postoperatively.

Keywords: glomangioma; glomus tumor; oncogenic osteomalacia; paranasal sinus tumor.

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Figures

Fig. 1
Fig. 1
Preoperative MRI, T1 with contrast, showing an ethmoid mass extending through the cribriform intracranially. Dimensions 3.9 × 1.9 × 2.4 cm.
Fig. 2
Fig. 2
Uniform clusters of ovoid cells arranged around vessels with moderate nuclear enlargement. H&E, 200x.
Fig. 3
Fig. 3
Tumor cells stained positive for CD31. 200x.
Fig. 4
Fig. 4
Postoperative MRI, T1 with contrast, showing gross total resection of the mass with nasoseptal flap reconstruction of the skull base.
See this image and copyright information in PMC

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