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. 2017 Jan 18:11:122-126.
doi: 10.1016/j.dib.2016.12.023. eCollection 2017 Apr.

Identification of diagnostic markers involved in the pathogenesis of gastric cancer through iTRAQ-based quantitative proteomics

Zhen Jiang  1 , Hongchun Shen  2 , Bo Tang  3 , Hui Chen  1 , Qin Yu  4 , Xingli Ji  4 , Li Wang  4
Affiliations

Identification of diagnostic markers involved in the pathogenesis of gastric cancer through iTRAQ-based quantitative proteomics

Zhen Jiang et al. Data Brief. .

Abstract

We provide detailed datasets from our analysis of proteins that are differentially expressed in gastric cancer tissues compared with adjacent normal gastric tissues, as identified by iTRAQ-based quantitative proteomics. Also included is a set of representative images of immunohistochemical staining of gastric cancer tissues showing four levels of expression of fatty acid binding protein (FABP1) and fatty acid synthase (FASN). The data presented in this paper support the research article "Quantitative proteomic analysis reveals that proteins required for fatty acid metabolism may serve as diagnostic markers for gastric cancer" (Jiang et al., 2017) [1]. We expect that the data will contribute to the identification of sensitive and specific biomarkers for early detection of gastric cancer.

Keywords: ESI, electrospray ionization; FABP1, fatty acid binding protein; FASN, fatty acid synthase; GC, gastric cancer; LC, liquid chromatography; MS/MS, tandem mass spectrometry; iTRAQ, isobaric tag for relative and absolute quantitation.

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Figures

Fig. 1.
Fig. 1
Representative images of immunohistochemical staining levels of FABP1 in gastric cancer tissues. (A) absent [0], (B) weak [1], (C) moderate [2], and (D) strong [3].
Fig. 2.
Fig. 2
Representative images of immunohistochemical staining levels of FASN in gastric cancer tissues. (A) absent [0], (B) weak [1], (C) moderate [2], and (D) strong [3].
See this image and copyright information in PMC

References

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