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Review
. 2017 Feb 9:7:41683.
doi: 10.1038/srep41683.

Associations between polymorphisms of the ADIPOQ gene and hypertension risk: a systematic and meta-analysis

Weina Fan  1 , Xiaowei Qu  2 , Jing Li  3 , Xingning Wang  2 , Yanping Bai  4 , Qingmei Cao  2 , Liqun Ma  5 , Xiaoyao Zhou  6 , Wei Zhu  7 , Wei Liu  4 , Qiang Ma  8
Affiliations
Review

Associations between polymorphisms of the ADIPOQ gene and hypertension risk: a systematic and meta-analysis

Weina Fan et al. Sci Rep. .

Abstract

ADIPOQ gene polymorphisms have been indicated to be associated with hypertension; however, published studies have reported inconsistent results. Eligible studies were retrieved by searching the PubMed, Embase and China National Knowledge Infrastructure databases. The case group consisted of patients with hypertension, and the control group consisted of subjects with normal blood pressure. Based on eleven published articles, involving 4837 cases and 5618 controls, the pooled results from rs2241766 polymorphism showed increased risk in the allelic model (G VS T: OR = 1.16, 95%CI = 1.06-1.27), recessive model (GG VS GT + TT: OR = 1.34, 95%CI = 1.10-1.63), dominant model (GG + GT VS TT: OR = 1.15, 95%CI = 1.02-1.30) and homozygote model (GG VS TT: OR = 1.38, 95%CI = 1.21-1.69). In addition, rs266729 polymorphism showed increased risk for hypertension in the recessive model (GG VS GC + CC: OR = 1.43, 95%CI = 1.02-2.01). In the Caucasian subgroup, rs1501299 polymorphism showed decreased risk of hypertension in the allelic model (T VS G: OR = 0.75, 95%CI = 0.58-0.97), dominant model (TT + TG VS GG: OR = 0.83, 95%CI = 0.71-0.98) and heterozygote model (TG VS GG: OR = 0.82, 95%CI = 0.68-0.99). The rs2241766 polymorphism was associated with a significant increase in hypertension risk based on our analysis. Moreover, an increased risk of rs266729 in hypertension patients was also detected. Our meta-analysis suggests that the rs1501299 polymorphism may play a protective role in hypertension in Caucasian subgroup; however, this finding requires further study.

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Conflict of interest statement

The authors declare no competing financial interests.

Figures

Figure 1
Figure 1. Forest plot of hypertension risk associated with the GG genotype in ADIPOQ rs2241766 polymorphism.
OR = odd ration, CI = confidence interval.
Figure 2
Figure 2. Forest plot of hypertension risk associated with the T allele compared with the G allele in ADIPOQ rs1501299 polymorphism.
OR = odd ration, CI = confidence interval.
Figure 3
Figure 3. Forest plot of hypertension risk associated with the GG genotype in ADIPOQ rs266729 polymorphism in subgroup analysis of ethnicity.
OR = odd ration, CI = confidence interval.
Figure 4
Figure 4. Influence analysis of rs2241766 polymorphism and hypertension risk.
(A) Allelic genetic model analysis. (B) Recessive genetic model analysis. (C) Heterozygote genetic model analysis. (D) Homozygote genetic model analysis.
Figure 5
Figure 5. Influence analysis of rs1501299 polymorphism and hypertension risk.
(A) Recessive genetic model analysis. (B) Dominant genetic model analysis. (C) Heterozygote genetic model analysis. (D) Homozygote genetic model analysis.
Figure 6
Figure 6. Influence analysis of rs266729 polymorphism and hypertension risk.
(A) Recessive genetic model analysis. (B) Dominant genetic model analysis. (C) Heterozygote genetic model analysis. (D) Homozygote genetic model analysis.
Figure 7
Figure 7. Begg’s funnel plot for contrast in overall analysis in recessive model.
Each point represents a separate study for the indicated association. Size graph symbol by weighs. Log [OR] natural logarithm of OR. Horizontal line means effect size.
See this image and copyright information in PMC

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