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. 2017 Feb 17;19(4):942-945.
doi: 10.1021/acs.orglett.7b00145. Epub 2017 Feb 9.

Versicoamides F-H, Prenylated Indole Alkaloids from Aspergillus tennesseensis

Li Liu  1   2 , Long Wang  1 , Li Bao  1   2 , Jinwei Ren  1   2 , Buddha Bahadur Basnet  1   3 , Ruixing Liu  1   2 , Luwei He  1   2 , Junjie Han  1 , Wen-Bing Yin  1   2 , Hongwei Liu  1   2
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Versicoamides F-H, Prenylated Indole Alkaloids from Aspergillus tennesseensis

Li Liu et al. Org Lett. .

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Abstract

Three highly modified indole alkaloids, versicoamides F-H (1-3), together with seven known alkaloids (4-10) were isolated from the fungus Aspergillus tennesseensis. The structures of new compounds were determined by analysis of the NMR and MS spectroscopic data. The absolute configurations of 1 and 2 were assigned by single-crystal X-ray diffraction experiments. Compounds 1 and 2 showed weak antiproliferative activity against the H460 cell line. Compounds 1-3 represent a new class of natural product hybrids with new chemical skeletons.

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