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. 2017 Feb 9;8(2):e2604.

doi: 10.1038/cddis.2016.353.

Arginylation: a new regulator of mRNA stability and heat stress response

Kamalakshi Deka¹, Sougata Saha¹

Affiliations

PMID: 28182016
PMCID: PMC5386450
DOI: 10.1038/cddis.2016.353

Arginylation: a new regulator of mRNA stability and heat stress response

Kamalakshi Deka et al. Cell Death Dis. 2017.

. 2017 Feb 9;8(2):e2604.

doi: 10.1038/cddis.2016.353.

Authors

Kamalakshi Deka¹, Sougata Saha¹

Affiliation

¹ Department of Molecular Biology and Biotechnology, Tezpur University, Napaam, Assam 784028, India.

PMID: 28182016
PMCID: PMC5386450
DOI: 10.1038/cddis.2016.353

No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Protein arginylation plays a protective role during heat stress. (a) Arginylation of an unknown target facilitates HSP mRNA stabilization leading to sustained expression of HSP proteins and cellular protection by maintaining mitochondrial integrity and inhibition of apoptosis. (b) Cells lacking arginylation fails to stabilize HSP mRNA possibly due to absence of arginylation in key protein/s. This causes insufficient level of HSP proteins resulting in weak stress response and cell death

See this image and copyright information in PMC

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