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Review
. 2017 Jan 25:11:273-293.
doi: 10.2147/DDDT.S60973. eCollection 2017.

Drugs in development for toxoplasmosis: advances, challenges, and current status

P Holland Alday  1 , Joseph Stone Doggett  2
Affiliations
Review

Drugs in development for toxoplasmosis: advances, challenges, and current status

P Holland Alday et al. Drug Des Devel Ther. .

Abstract

Toxoplasma gondii causes fatal and debilitating brain and eye diseases. Medicines that are currently used to treat toxoplasmosis commonly have toxic side effects and require prolonged courses that range from weeks to more than a year. The need for long treatment durations and the risk of relapsing disease are in part due to the lack of efficacy against T. gondii tissue cysts. The challenges for developing a more effective treatment for toxoplasmosis include decreasing toxicity, achieving therapeutic concentrations in the brain and eye, shortening duration, eliminating tissue cysts from the host, safety in pregnancy, and creating a formulation that is inexpensive and practical for use in resource-poor areas of the world. Over the last decade, significant progress has been made in identifying and developing new compounds for the treatment of toxoplasmosis. Unlike clinically used medicines that were repurposed for toxoplasmosis, these compounds have been optimized for efficacy against toxoplasmosis during preclinical development. Medicines with enhanced efficacy as well as features that address the unique aspects of toxoplasmosis have the potential to greatly improve toxoplasmosis therapy. This review discusses the facets of toxoplasmosis that are pertinent to drug design and the advances, challenges, and current status of preclinical drug research for toxoplasmosis.

Keywords: Apicomplexa; Toxoplasma gondii; experimental medicine; mechanism of action; preclinical medicine; therapeutics.

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Conflict of interest statement

The authors report no conflicts of interest in this work.

References

    1. Tenter AM, Heckeroth AR, Weiss LM. Toxoplasma gondii: from animals to humans. Int J Parasitol. 2000;30(12–13):1217–1258. - PMC - PubMed
    1. Jones JL, Akstein RB, Hlavsa MC, Lopez AS, Wilson M, Holland GN. Follow-up of the 1977 Georgia outbreak of toxoplasmosis. Am J Trop Med Hyg. 2016;94(6):1299–1300. - PMC - PubMed
    1. Vaudaux JD, Muccioli C, James ER, et al. Identification of an atypical strain of toxoplasma gondii as the cause of a waterborne outbreak of toxoplasmosis in Santa Isabel do Ivai, Brazil. J Infect Dis. 2010;202(8):1226–1233. - PMC - PubMed
    1. Bowie WR, King AS, Werker DH, et al. Outbreak of toxoplasmosis associated with municipal drinking water. The BC Toxoplasma Investigation Team. Lancet. 1997;350(9072):173–177. - PubMed
    1. Pappas G, Roussos N, Falagas ME. Toxoplasmosis snapshots: global status of Toxoplasma gondii seroprevalence and implications for pregnancy and congenital toxoplasmosis. Int J Parasitol. 2009;39(12):1385–1394. - PubMed

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