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Editorial
. 2017 Jan 21;38(4):289-291.
doi: 10.1093/eurheartj/ehv635.

Familial inappropriate sinus tachycardia: a new chapter in the story of HCN4 channelopathies

Vasanth Vedantham  1 , Melvin M Scheinman  1
Affiliations
Editorial

Familial inappropriate sinus tachycardia: a new chapter in the story of HCN4 channelopathies

Vasanth Vedantham et al. Eur Heart J. .
No abstract available

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Figures

Figure 1
Figure 1
Role of Hcn4 in the pathophysiology of inappropriate sinus tachycardia (IST). This diagram illustrates the role of increased funny current in the context of proposed causes of IST, including increased pacemaker cell automaticity, increased sympathetic activity, activating anti-beta-adrenergic antibodies, anxiety, and the R524Q mutation in the Hcn4 C-linker, which increases the sensitivity of Hcn4 to cAMP. In theory, these mechanisms are not mutually exclusive and could be synergistic. β-AR, beta-adrenergic receptor.
See this image and copyright information in PMC

Comment on

References

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