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. 2017 Feb 9;13(2):e1005339.
doi: 10.1371/journal.pcbi.1005339. eCollection 2017 Feb.

Estimating the Respective Contributions of Human and Viral Genetic Variation to HIV Control

István Bartha  1   2 , Paul J McLaren  3   4 , Chanson Brumme  5 , Richard Harrigan  5 , Amalio Telenti  6 , Jacques Fellay  1   2
Affiliations

Estimating the Respective Contributions of Human and Viral Genetic Variation to HIV Control

István Bartha et al. PLoS Comput Biol. .

Abstract

We evaluated the fraction of variation in HIV-1 set point viral load attributable to viral or human genetic factors by using joint host/pathogen genetic data from 541 HIV infected individuals. We show that viral genetic diversity explains 29% of the variation in viral load while host factors explain 8.4%. Using a joint model including both host and viral effects, we estimate a total of 30% heritability, indicating that most of the host effects are reflected in viral sequence variation.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Illustration of fractions of explained variances by models taking human HLA, viral sequence similarities, or both into account.
See this image and copyright information in PMC

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