Strange New World: Bacteria Catalyze Ubiquitylation via ADP Ribosylation

David Komander¹, Felix Randow²

Affiliations

¹ MRC Laboratory of Molecular Biology, Division of Protein and Nucleic Acid Chemistry, Francis Crick Avenue, Cambridge CB2 0QH, UK. Electronic address: dk@mrc-lmb.cam.ac.uk.
² MRC Laboratory of Molecular Biology, Division of Protein and Nucleic Acid Chemistry, Francis Crick Avenue, Cambridge CB2 0QH, UK; University of Cambridge, Department of Medicine, Addenbrooke's Hospital, Cambridge CB2 0QQ, UK. Electronic address: randow@mrc-lmb.cam.ac.uk.

PMID: 28182945
DOI: 10.1016/j.chom.2017.01.014

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Strange New World: Bacteria Catalyze Ubiquitylation via ADP Ribosylation

David Komander et al. Cell Host Microbe. 2017.

Free article

. 2017 Feb 8;21(2):127-129.

doi: 10.1016/j.chom.2017.01.014.

Authors

David Komander¹, Felix Randow²

Affiliations

¹ MRC Laboratory of Molecular Biology, Division of Protein and Nucleic Acid Chemistry, Francis Crick Avenue, Cambridge CB2 0QH, UK. Electronic address: dk@mrc-lmb.cam.ac.uk.
² MRC Laboratory of Molecular Biology, Division of Protein and Nucleic Acid Chemistry, Francis Crick Avenue, Cambridge CB2 0QH, UK; University of Cambridge, Department of Medicine, Addenbrooke's Hospital, Cambridge CB2 0QQ, UK. Electronic address: randow@mrc-lmb.cam.ac.uk.

PMID: 28182945
DOI: 10.1016/j.chom.2017.01.014

Abstract

Three recent papers, including one by Kotewicz et al. (2016) in this issue of Cell Host & Microbe, show that Legionella deploys a novel form of ubiquitylation to generate its replicative vacuole. Without E1 and E2 enzymes, SidE effectors ubiquitylate serine residues in substrates via an ADP-ribosylated ubiquitin intermediate.

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A Single Legionella Effector Catalyzes a Multistep Ubiquitination Pathway to Rearrange Tubular Endoplasmic Reticulum for Replication.
Kotewicz KM, Ramabhadran V, Sjoblom N, Vogel JP, Haenssler E, Zhang M, Behringer J, Scheck RA, Isberg RR. Kotewicz KM, et al. Cell Host Microbe. 2017 Feb 8;21(2):169-181. doi: 10.1016/j.chom.2016.12.007. Epub 2016 Dec 29. Cell Host Microbe. 2017. PMID: 28041930 Free PMC article.

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Strange New World: Bacteria Catalyze Ubiquitylation via ADP Ribosylation

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Strange New World: Bacteria Catalyze Ubiquitylation via ADP Ribosylation

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