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. 2017 Feb 2;22(5):30455.
doi: 10.2807/1560-7917.ES.2017.22.5.30455.

Emergence of the lymphogranuloma venereum L2c genovariant, Hungary, 2012 to 2016

Fruzsina Petrovay  1 , Eszter Balla  1 , Tímea Erdősi  2
Affiliations

Emergence of the lymphogranuloma venereum L2c genovariant, Hungary, 2012 to 2016

Fruzsina Petrovay et al. Euro Surveill. .

Abstract

In eastern Europe, few countries have so far reported laboratory-confirmed cases of lymphogranuloma venereum (LGV). Here we describe 22 LGV cases in men who have sex with men (MSM) detected in Hungary from November 2012 to July 2016. Sequence analyses show that 16 of these 22 cases were affected by the L2c genovariant, with from 2012 to 2014, one LGV L2c case detected per year, followed by seven cases in 2015 and six up to July 2016. Of the 16 total L2c LGV cases, 10 had severe haemorrhagic proctitis. These findings are concerning as cases with this new genovariant among MSM have not been frequently reported in Europe to date. More research is needed to assess the spread of the L2c genovariant and its potential association with virulence and severe clinical manifestation.

Keywords: Chlamydia trachomatis; L2c genovariant; lymphogranuloma venereum (LGV); men who have sex with men (MSM).

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Conflict of interest statement

Conflict of interest: None declared.

Comment in

References

    1. European Centre for Disease Prevention and Control (ECDC). Sexually transmitted infections in Europe 2013. Stockholm: ECDC; 2015.
    1. Childs T, Simms I, Alexander S, Eastick K, Hughes G, Field N. Rapid increase in lymphogranuloma venereum in men who have sex with men, United Kingdom, 2003 to September 2015. Euro Surveill. 2015;20(48):30076. 10.2807/1560-7917.ES.2015.20.48.30076 - DOI - PubMed
    1. Vanousova D, Zakoucka H, Jilich D, Rozsypal H, Stankova M, Zufanova S, et al. First detection of Chlamydia trachomatis LGV biovar in the Czech Republic, 2010-2011. Euro Surveill. 2012;17(2):20055. - PubMed
    1. Balla E, Petrovay F, Mag T, Balázs A, Erdősi T, Együd K, et al. Confirmed cases of lymphogranuloma venereum in Hungary, 2012-2014: supportive diagnostic tool of immunoblotting. Sex Transm Infect. 2015;91(3):200. 10.1136/sextrans-2014-051673 - DOI - PubMed
    1. Matičič M, Klavs I, Videčnik Zorman J, Vidmar Vovko D, Kogoj R, Keše D. Confirmed inguinal lymphogranuloma venereum genovar L2c in a man who had sex with men, Slovenia, 2015. Euro Surveill. 2016;21(5):30129. 10.2807/1560-7917.ES.2016.21.5.30129 - DOI - PubMed

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