. 2017 Jul;13(7):727-738.

doi: 10.1016/j.jalz.2016.12.012. Epub 2017 Feb 7.

Transethnic genome-wide scan identifies novel Alzheimer's disease loci

Gyungah R Jun¹, Jaeyoon Chung², Jesse Mez³, Robert Barber⁴, Gary W Beecham⁵, David A Bennett⁶, Joseph D Buxbaum⁷, Goldie S Byrd⁸, Minerva M Carrasquillo⁹, Paul K Crane¹⁰, Carlos Cruchaga¹¹, Philip De Jager¹², Nilufer Ertekin-Taner⁹, Denis Evans¹³, M Danielle Fallin¹⁴, Tatiana M Foroud¹⁵, Robert P Friedland¹⁶, Alison M Goate¹⁷, Neill R Graff-Radford⁹, Hugh Hendrie¹⁸, Kathleen S Hall¹⁹, Kara L Hamilton-Nelson⁵, Rivka Inzelberg²⁰, M Ilyas Kamboh²¹, John S K Kauwe²², Walter A Kukull²³, Brian W Kunkle⁵, Ryozo Kuwano²⁴, Eric B Larson²⁵, Mark W Logue²⁶, Jennifer J Manly²⁷, Eden R Martin⁵, Thomas J Montine²⁸, Shubhabrata Mukherjee¹⁰, Adam Naj²⁹, Eric M Reiman³⁰, Christiane Reitz³¹, Richard Sherva², Peter H St George-Hyslop³², Timothy Thornton¹⁰, Steven G Younkin⁹, Badri N Vardarajan³³, Li-San Wang³⁴, Jens R Wendlund³⁵, Ashley R Winslow³⁵; Alzheimer's Disease Genetics Consortium; Jonathan Haines³⁶, Richard Mayeux³⁷, Margaret A Pericak-Vance⁵, Gerard Schellenberg³⁴, Kathryn L Lunetta³⁸, Lindsay A Farrer³⁹

Collaborators, Affiliations

Collaborators

Alzheimer's Disease Genetics Consortium:
Perrie M Adams, Marilyn S Albert, Roger L Albin, Liana G Apostolova, Steven E Arnold, Sanjay Asthana, Craig S Atwood, Michjael M Barmada, Lisa L Barnes, Thomas G Beach, James T Becker, Eileen H Bigio, Thomas D Bird, Deborah Blacker, Bradley F Boeve, James D Bowen, Adam Boxer, James R Burke, Nigel J Cairns, Chuanhai Cao, Chris S Carlson, Cynthia M Carlsson, Regina M Carney, Minerva M Carrasquillo, Steven L Carroll, Helena C Chui, David G Clark, Jason Corneveaux, David H Cribbs, Elizabeth A Crocco, Carlos Cruchaga, Philip L De Jager, Charles DeCarli, Steven T DeKosky, F Yesim Demirci, Malcolm Dick, Dennis W Dickson, Rachelle S Doody, Ranjan Duara, Nilufer Ertekin-Taner, Kelley M Faber, Thomas J Fairchild, Kenneth B Fallon, Martin R Farlow, Steven Ferris, Matthew P Frosch, Douglas R Galasko, Marla Gearing, Daniel H Geschwind, Bernardino Ghetti, John R Gilbert, Jonathan D Glass, Neill R Graff-Radford, Robert C Green, John H Growdon, Hakon Hakonarson, Ronald L Hamilton, John Hardy, Lindy E Harrell, Elizabeth Head, Lawrence S Honig, Ryan M Huebinger, Matthew J Huentelman, Christine M Hulette, Bradley T Hyman, Gail P Jarvik, Gregory A Jicha, Lee-Way Jin, Anna Karydas, John S K Kauwe, Jeffrey A Kaye, Ronald Kim, Edward H Koo, Neil W Kowall, Joel H Kramer, Frank M LaFerla, James J Lah, James B Leverenz, Allan I Levey, Ge Li, Andrew P Lieberman, Chiao-Feng Lin, Oscar L Lopez, Constantine G Lyketsos, Wendy J Mack, Daniel C Marson, Frank Martiniuk, Deborah C Mash, Eliezer Masliah, Wayne C McCormick, Susan M McCurry, Andrew N McDavid, Ann C McKee, Marsel Mesulam, Bruce L Miller, Carol A Miller, Joshua W Miller, John C Morris, Shubhabrata Mukherjee, Jill R Murrell, Amanda J Myers, Sid O'Bryant, John M Olichney, Vernon S Pankratz, Joseph E Parisi, Amanda Partch, Henry L Paulson, William Perry, Elaine Peskind, Ronald C Petersen, Aimee Pierce, Wayne W Poon, Huntington Potter, Joseph F Quinn, Ashok Raj, Murray Raskind, Barry Reisberg, Joan S Reisch, Christiane Reitz, John M Ringman, Erik D Roberson, Ekaterina Rogaeva, Howard J Rosen, Roger N Rosenberg, Donald R Royall, Mark A Sager, Mary Sano, Andrew J Saykin, Julie A Schneider, Lon S Schneider, William W Seeley, Amanda G Smith, Joshua A Sonnen, Salvatore Spina, Robert A Stern, Rudolph E Tanzi, Tricia A Thornton-Wells, John Q Trojanowski, Juan C Troncoso, Debby W Tsuang, Vivianna M Van Deerlin, Linda J Van Eldik, Badri N Vardarajan, Harry V Vinters, Jean Paul Vonsattel, Sandra Weintraub, Kathleen A Welsh-Bohmer, Jennifer Williamson, Sarah Wishnek, Randall L Woltjer, Clinton B Wright, Chuang-Kuo Wu, Chang-En Yu, Lei Yu, Xiaoling Zhang

Affiliations

¹ Neurogenetics and Integrated Genomics, Andover Innovative Medicines Institute, Eisai Inc, Andover, MA, USA; Department of Medicine (Biomedical Genetics), Boston University Schools of Medicine, Boston, MA, USA.
² Department of Medicine (Biomedical Genetics), Boston University Schools of Medicine, Boston, MA, USA.
³ Department of Neurology, Boston University Schools of Medicine, Boston, MA, USA.
⁴ Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX, USA.
⁵ The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, USA.
⁶ Department of Neurological Sciences and Rush Alzheimer's Disease Center, Chicago, IL, USA.
⁷ Department of Neuroscience, Mount Sinai School of Medicine, New York, NY, USA; Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA; Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, NY, USA.
⁸ Department of Biology, North Carolina A&T State University, Greensboro, NC, USA.
⁹ Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
¹⁰ Department of Medicine, University of Washington, Seattle, WA, USA.
¹¹ Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University School of Medicine, St Louis, MO, USA; Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA.
¹² Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Neurology & Psychiatry, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.
¹³ Rush Institute for Healthy Aging, Department of Internal Medicine, Rush University Medical Center, Chicago, IL, USA.
¹⁴ Department of Mental Health, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
¹⁵ Department of Medical & Molecular Genetics, Indiana University, Indianapolis, IN, USA.
¹⁶ Department of Neurology, University of Louisville, Louisville, KY, USA.
¹⁷ Department of Neuroscience, Mount Sinai School of Medicine, New York, NY, USA.
¹⁸ Department of Psychiatry, Indiana University, Indianapolis, IN, USA; Regenstrief Institute, Inc, Indianapolis, IN, USA.
¹⁹ Regenstrief Institute, Inc, Indianapolis, IN, USA; Department of Medicine, Indiana University, Indianapolis, IN, USA.
²⁰ Department of Neurology and Neurosurgery, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
²¹ University of Pittsburgh Alzheimer's Disease Research Center and Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA, USA.
²² Department of Biology, Brigham Young University, Provo, UT, USA.
²³ Department of Epidemiology, University of Washington, Seattle, WA, USA; National Alzheimer's Coordinating Center, University of Washington, Seattle, WA, USA.
²⁴ Department of Molecular Genetics, Brain Research Institute, Niigata University, Niigata, Japan.
²⁵ Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA; Group Health, Group Health Research Institute, Seattle, WA, USA.
²⁶ Department of Medicine (Biomedical Genetics), Boston University Schools of Medicine, Boston, MA, USA; Department of Neurological Sciences and Rush Alzheimer's Disease Center, Chicago, IL, USA; National Center for PTSD, Behavioral Science Division, Boston VA Healthcare System, Boston, MA, USA.
²⁷ The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA; The Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
²⁸ Department of Pathology, Stanford University, Stanford, CA, USA.
²⁹ Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
³⁰ Arizona Alzheimer's Consortium, Phoenix, AZ, USA; Department of Psychiatry, University of Arizona, Phoenix, AZ, USA; Banner Alzheimer's Institute, Phoenix, AZ, USA; Neurogenomics Division, Translational Genomics Research Institute, Phoenix, AZ, USA.
³¹ The Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA; The Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY, USA; The Department of Epidemiology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
³² Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, Canada; Cambridge Institute for Medical Research and Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
³³ The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA; The Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA; The Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
³⁴ Arizona Alzheimer's Consortium, Phoenix, AZ, USA.
³⁵ PharmaTherapeutics Clinical Research, Pfizer Worldwide Research and Development, Cambridge, MA, USA.
³⁶ Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH, USA.
³⁷ The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA; The Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA; The Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA; The Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY, USA; The Department of Epidemiology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
³⁸ Department of Biostatistics, Boston University Schools of Public Health, Boston, MA, USA.
³⁹ Department of Medicine (Biomedical Genetics), Boston University Schools of Medicine, Boston, MA, USA; Department of Neurology, Boston University Schools of Medicine, Boston, MA, USA; Department of Biostatistics, Boston University Schools of Public Health, Boston, MA, USA; Department of Ophthalmology, Boston University Schools of Medicine, Boston, MA, USA; Department of Epidemiology, Boston University Schools of Public Health, Boston, MA, USA. Electronic address: farrer@bu.edu.

PMID: 28183528
PMCID: PMC5496797
DOI: 10.1016/j.jalz.2016.12.012

Transethnic genome-wide scan identifies novel Alzheimer's disease loci

Gyungah R Jun et al. Alzheimers Dement. 2017 Jul.

. 2017 Jul;13(7):727-738.

doi: 10.1016/j.jalz.2016.12.012. Epub 2017 Feb 7.

Authors

Collaborators

Alzheimer's Disease Genetics Consortium:
Perrie M Adams, Marilyn S Albert, Roger L Albin, Liana G Apostolova, Steven E Arnold, Sanjay Asthana, Craig S Atwood, Michjael M Barmada, Lisa L Barnes, Thomas G Beach, James T Becker, Eileen H Bigio, Thomas D Bird, Deborah Blacker, Bradley F Boeve, James D Bowen, Adam Boxer, James R Burke, Nigel J Cairns, Chuanhai Cao, Chris S Carlson, Cynthia M Carlsson, Regina M Carney, Minerva M Carrasquillo, Steven L Carroll, Helena C Chui, David G Clark, Jason Corneveaux, David H Cribbs, Elizabeth A Crocco, Carlos Cruchaga, Philip L De Jager, Charles DeCarli, Steven T DeKosky, F Yesim Demirci, Malcolm Dick, Dennis W Dickson, Rachelle S Doody, Ranjan Duara, Nilufer Ertekin-Taner, Kelley M Faber, Thomas J Fairchild, Kenneth B Fallon, Martin R Farlow, Steven Ferris, Matthew P Frosch, Douglas R Galasko, Marla Gearing, Daniel H Geschwind, Bernardino Ghetti, John R Gilbert, Jonathan D Glass, Neill R Graff-Radford, Robert C Green, John H Growdon, Hakon Hakonarson, Ronald L Hamilton, John Hardy, Lindy E Harrell, Elizabeth Head, Lawrence S Honig, Ryan M Huebinger, Matthew J Huentelman, Christine M Hulette, Bradley T Hyman, Gail P Jarvik, Gregory A Jicha, Lee-Way Jin, Anna Karydas, John S K Kauwe, Jeffrey A Kaye, Ronald Kim, Edward H Koo, Neil W Kowall, Joel H Kramer, Frank M LaFerla, James J Lah, James B Leverenz, Allan I Levey, Ge Li, Andrew P Lieberman, Chiao-Feng Lin, Oscar L Lopez, Constantine G Lyketsos, Wendy J Mack, Daniel C Marson, Frank Martiniuk, Deborah C Mash, Eliezer Masliah, Wayne C McCormick, Susan M McCurry, Andrew N McDavid, Ann C McKee, Marsel Mesulam, Bruce L Miller, Carol A Miller, Joshua W Miller, John C Morris, Shubhabrata Mukherjee, Jill R Murrell, Amanda J Myers, Sid O'Bryant, John M Olichney, Vernon S Pankratz, Joseph E Parisi, Amanda Partch, Henry L Paulson, William Perry, Elaine Peskind, Ronald C Petersen, Aimee Pierce, Wayne W Poon, Huntington Potter, Joseph F Quinn, Ashok Raj, Murray Raskind, Barry Reisberg, Joan S Reisch, Christiane Reitz, John M Ringman, Erik D Roberson, Ekaterina Rogaeva, Howard J Rosen, Roger N Rosenberg, Donald R Royall, Mark A Sager, Mary Sano, Andrew J Saykin, Julie A Schneider, Lon S Schneider, William W Seeley, Amanda G Smith, Joshua A Sonnen, Salvatore Spina, Robert A Stern, Rudolph E Tanzi, Tricia A Thornton-Wells, John Q Trojanowski, Juan C Troncoso, Debby W Tsuang, Vivianna M Van Deerlin, Linda J Van Eldik, Badri N Vardarajan, Harry V Vinters, Jean Paul Vonsattel, Sandra Weintraub, Kathleen A Welsh-Bohmer, Jennifer Williamson, Sarah Wishnek, Randall L Woltjer, Clinton B Wright, Chuang-Kuo Wu, Chang-En Yu, Lei Yu, Xiaoling Zhang

Affiliations

¹ Neurogenetics and Integrated Genomics, Andover Innovative Medicines Institute, Eisai Inc, Andover, MA, USA; Department of Medicine (Biomedical Genetics), Boston University Schools of Medicine, Boston, MA, USA.
² Department of Medicine (Biomedical Genetics), Boston University Schools of Medicine, Boston, MA, USA.
³ Department of Neurology, Boston University Schools of Medicine, Boston, MA, USA.
⁴ Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX, USA.
⁵ The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, USA.
⁶ Department of Neurological Sciences and Rush Alzheimer's Disease Center, Chicago, IL, USA.
⁷ Department of Neuroscience, Mount Sinai School of Medicine, New York, NY, USA; Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA; Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, NY, USA.
⁸ Department of Biology, North Carolina A&T State University, Greensboro, NC, USA.
⁹ Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
¹⁰ Department of Medicine, University of Washington, Seattle, WA, USA.
¹¹ Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University School of Medicine, St Louis, MO, USA; Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA.
¹² Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Neurology & Psychiatry, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.
¹³ Rush Institute for Healthy Aging, Department of Internal Medicine, Rush University Medical Center, Chicago, IL, USA.
¹⁴ Department of Mental Health, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
¹⁵ Department of Medical & Molecular Genetics, Indiana University, Indianapolis, IN, USA.
¹⁶ Department of Neurology, University of Louisville, Louisville, KY, USA.
¹⁷ Department of Neuroscience, Mount Sinai School of Medicine, New York, NY, USA.
¹⁸ Department of Psychiatry, Indiana University, Indianapolis, IN, USA; Regenstrief Institute, Inc, Indianapolis, IN, USA.
¹⁹ Regenstrief Institute, Inc, Indianapolis, IN, USA; Department of Medicine, Indiana University, Indianapolis, IN, USA.
²⁰ Department of Neurology and Neurosurgery, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
²¹ University of Pittsburgh Alzheimer's Disease Research Center and Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA, USA.
²² Department of Biology, Brigham Young University, Provo, UT, USA.
²³ Department of Epidemiology, University of Washington, Seattle, WA, USA; National Alzheimer's Coordinating Center, University of Washington, Seattle, WA, USA.
²⁴ Department of Molecular Genetics, Brain Research Institute, Niigata University, Niigata, Japan.
²⁵ Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA; Group Health, Group Health Research Institute, Seattle, WA, USA.
²⁶ Department of Medicine (Biomedical Genetics), Boston University Schools of Medicine, Boston, MA, USA; Department of Neurological Sciences and Rush Alzheimer's Disease Center, Chicago, IL, USA; National Center for PTSD, Behavioral Science Division, Boston VA Healthcare System, Boston, MA, USA.
²⁷ The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA; The Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
²⁸ Department of Pathology, Stanford University, Stanford, CA, USA.
²⁹ Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
³⁰ Arizona Alzheimer's Consortium, Phoenix, AZ, USA; Department of Psychiatry, University of Arizona, Phoenix, AZ, USA; Banner Alzheimer's Institute, Phoenix, AZ, USA; Neurogenomics Division, Translational Genomics Research Institute, Phoenix, AZ, USA.
³¹ The Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA; The Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY, USA; The Department of Epidemiology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
³² Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, Canada; Cambridge Institute for Medical Research and Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
³³ The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA; The Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA; The Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
³⁴ Arizona Alzheimer's Consortium, Phoenix, AZ, USA.
³⁵ PharmaTherapeutics Clinical Research, Pfizer Worldwide Research and Development, Cambridge, MA, USA.
³⁶ Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH, USA.
³⁷ The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA; The Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA; The Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA; The Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY, USA; The Department of Epidemiology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
³⁸ Department of Biostatistics, Boston University Schools of Public Health, Boston, MA, USA.
³⁹ Department of Medicine (Biomedical Genetics), Boston University Schools of Medicine, Boston, MA, USA; Department of Neurology, Boston University Schools of Medicine, Boston, MA, USA; Department of Biostatistics, Boston University Schools of Public Health, Boston, MA, USA; Department of Ophthalmology, Boston University Schools of Medicine, Boston, MA, USA; Department of Epidemiology, Boston University Schools of Public Health, Boston, MA, USA. Electronic address: farrer@bu.edu.

PMID: 28183528
PMCID: PMC5496797
DOI: 10.1016/j.jalz.2016.12.012

Abstract

Introduction: Genetic loci for Alzheimer's disease (AD) have been identified in whites of European ancestry, but the genetic architecture of AD among other populations is less understood.

Methods: We conducted a transethnic genome-wide association study (GWAS) for late-onset AD in Stage 1 sample including whites of European Ancestry, African-Americans, Japanese, and Israeli-Arabs assembled by the Alzheimer's Disease Genetics Consortium. Suggestive results from Stage 1 from novel loci were followed up using summarized results in the International Genomics Alzheimer's Project GWAS dataset.

Results: Genome-wide significant (GWS) associations in single-nucleotide polymorphism (SNP)-based tests (P < 5 × 10^-8) were identified for SNPs in PFDN1/HBEGF, USP6NL/ECHDC3, and BZRAP1-AS1 and for the interaction of the (apolipoprotein E) APOE ε4 allele with NFIC SNP. We also obtained GWS evidence (P < 2.7 × 10^-6) for gene-based association in the total sample with a novel locus, TPBG (P = 1.8 × 10^-6).

Discussion: Our findings highlight the value of transethnic studies for identifying novel AD susceptibility loci.

Keywords: APOE interaction; Alzheimer's disease; Genome-wide association; Transethnic.

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Figures

**Figure 1**
Regional association plots in the combined stage 1 and stage 2 sample including main effects at **(A)** *PFDN1/HBEGF*, **(B)** *USP6NL/ECHDC3*, **(C)** *BZRAP1-AS1*, and **(D)** SNP**APOE* ε4 interaction near *NFIC*.

**Figure 2**
Forest plots for by ethnicity and stage for **(A)** rs11168036 atPFDN1/HBEGF, **(B)** rs7920721 at *USP6NL/ECHDC3*, **(C)** rs2632516 at *BZRAP1-AS1,* **(D)** *NFIC* rs9749589**APOE* ε4 interaction.

See this image and copyright information in PMC

References

1. Association As 2014 Alzheimer's disease facts and figures. Alzheimers Dement. 2014;10:e47–92. - PubMed
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1. Farrer LA, Cupples LA, Haines JL, Hyman B, Kukull WA, Mayeux R, et al. Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium. Jama. 1997;278:1349–56. - PubMed
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Transethnic genome-wide scan identifies novel Alzheimer's disease loci

Collaborators

Affiliations

Transethnic genome-wide scan identifies novel Alzheimer's disease loci

Authors

Collaborators

Affiliations

Abstract

Figures

References

MeSH terms

Substances

Grants and funding

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Molecular Biology Databases

Miscellaneous