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Review
. 2017 Jun 1;28(6):1230-1242.
doi: 10.1093/annonc/mdx054.

Best practices for the management of local-regional recurrent chordoma: a position paper by the Chordoma Global Consensus Group

S Stacchiotti  1 , A Gronchi  2 , P Fossati  3   4 , T Akiyama  5 , C Alapetite  6   7 , M Baumann  8 , J Y Blay  9 , S Bolle  10 , S Boriani  11 , P Bruzzi  12 , R Capanna  13 , A Caraceni  14 , R Casadei  15 , V Colia  1 , J Debus  16 , T Delaney  17 , A Desai  18 , P Dileo  19 , S Dijkstra  20 , F Doglietto  21 , A Flanagan  22   23 , S Froelich  24 , P A Gardner  25 , H Gelderblom  26 , Z L Gokaslan  27 , R Haas  28 , C Heery  29 , N Hindi  30 , P Hohenberger  31 , F Hornicek  32 , R Imai  33 , L Jeys  34 , R L Jones  35 , B Kasper  31 , A Kawai  36 , M Krengli  37 , A Leithner  38 , I Logowska  39 , J Martin Broto  30 , D Mazzatenta  40 , C Morosi  41 , P Nicolai  42 , O J Norum  43 , S Patel  44 , N Penel  45 , P Picci  46 , S Pilotti  47 , S Radaelli  2 , F Ricchini  14 , P Rutkowski  39 , S Scheipl  38 , C Sen  48 , E Tamborini  47 , K A Thornton  49 , B Timmermann  50 , V Torri  51 , P U Tunn  52 , M Uhl  16 , Y Yamada  53 , D C Weber  54 , D Vanel  55 , P P Varga  56 , C L A Vleggeert-Lankamp  57 , P G Casali  1 , J Sommer  58
Affiliations
Review

Best practices for the management of local-regional recurrent chordoma: a position paper by the Chordoma Global Consensus Group

S Stacchiotti et al. Ann Oncol. .

Abstract

Chordomas are rare, malignant bone tumors of the skull-base and axial skeleton. Until recently, there was no consensus among experts regarding appropriate clinical management of chordoma, resulting in inconsistent care and suboptimal outcomes for many patients. To address this shortcoming, the European Society of Medical Oncology (ESMO) and the Chordoma Foundation, the global chordoma patient advocacy group, convened a multi-disciplinary group of chordoma specialists to define by consensus evidence-based best practices for the optimal approach to chordoma. In January 2015, the first recommendations of this group were published, covering the management of primary and metastatic chordomas. Additional evidence and further discussion were needed to develop recommendations about the management of local-regional failures. Thus, ESMO and CF convened a second consensus group meeting in November 2015 to address the treatment of locally relapsed chordoma. This meeting involved over 60 specialists from Europe, the United States and Japan with expertise in treatment of patients with chordoma. The consensus achieved during that meeting is the subject of the present publication and complements the recommendations of the first position paper.

Keywords: chemotherapy; chordoma; radiotherapy; relapse; sarcoma; surgery.

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Figures

Figure 1.
Figure 1.
Flow-charts summarizing the recommended treatment strategy for patients with local-regional recurrence. MR, magnetic resonance; CT, computerized tomography; prog., progressioni; WB, whole body; REF, reference; RT, radiotherapy.
See this image and copyright information in PMC

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