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Review
. 2017 May;44(4-5):785-797.
doi: 10.1007/s10295-017-1913-4. Epub 2017 Feb 9.

Advancement in bioprocess technology: parallels between microbial natural products and cell culture biologics

Arpan A Bandyopadhyay  1 , Anurag Khetan  2 , Li-Hong Malmberg  3 , Weichang Zhou  4 , Wei-Shou Hu  5
Affiliations
Review

Advancement in bioprocess technology: parallels between microbial natural products and cell culture biologics

Arpan A Bandyopadhyay et al. J Ind Microbiol Biotechnol. 2017 May.

Abstract

The emergence of natural products and industrial microbiology nearly eight decades ago propelled an era of bioprocess innovation. Half a century later, recombinant protein technology spurred the tremendous growth of biologics and added mammalian cells to the forefront of industrial producing cells in terms of the value of products generated. This review highlights the process technology of natural products and protein biologics. Despite the separation in time, there is a remarkable similarity in their progression. As the new generation of therapeutics for gene and cell therapy emerges, its process technology development can take inspiration from that of natural products and biologics.

Keywords: Natural products; Process technology; Protein biologics.

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